Flavonoids and Related Members of the Aromatic Polyketide Group in Human Health and Disease: Do They Really Work?
Autor: | Silvie Rimpelová, Jan Tauchen, Michal Jurášek, Lukáš Huml |
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Rok vydání: | 2020 |
Předmět: |
clinical significance
Pharmaceutical Science Review Disease anticancer Bioinformatics Antioxidants Analytical Chemistry dietary supplements lcsh:QD241-441 03 medical and health sciences Human health Polyketide 0302 clinical medicine lcsh:Organic chemistry Drug Discovery Medicine Humans Physical and Theoretical Chemistry Drug pipeline Beneficial effects 030304 developmental biology Flavonoids 0303 health sciences Clinical Trials as Topic business.industry Organic Chemistry Phenoxodiol Additional research Clinical trial nutrition Chemistry (miscellaneous) 030220 oncology & carcinogenesis Polyketides Molecular Medicine business |
Zdroj: | Molecules, Vol 25, Iss 3846, p 3846 (2020) Molecules |
ISSN: | 1420-3049 |
Popis: | Some aromatic polyketides such as dietary flavonoids have gained reputation as miraculous molecules with preeminent beneficial effects on human health, for example, as antioxidants. However, there is little conclusive evidence that dietary flavonoids provide significant leads for developing more effective drugs, as the majority appears to be of negligible medicinal importance. Some aromatic polyketides of limited distribution have shown more interesting medicinal properties and additional research should be focused on them. Combretastatins, analogues of phenoxodiol, hepatoactive kavalactones, and silymarin are showing a considerable promise in the advanced phases of clinical trials for the treatment of various pathologies. If their limitations such as adverse side effects, poor water solubility, and oral inactivity are successfully eliminated, they might be prime candidates for the development of more effective and in some case safer drugs. This review highlights some of the newer compounds, where they are in the new drug pipeline and how researchers are searching for additional likely candidates. |
Databáze: | OpenAIRE |
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