Loss of Humoral and Cellular Immunity to Invasive Nontyphoidal Salmonella during Current or Convalescent Plasmodium falciparum Infection in Malawian Children
| Autor: | Queen Dube, Tonney S. Nyirenda, James T. Nyirenda, Kondwani C. Jambo, Robert S. Heyderman, Chisomo L. Msefula, Henry C. Mwandumba, Wilson L. Mandala, Melita A. Gordon, Janet Storm, Dumizulu L. Tembo |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Salmonella typhimurium 0301 basic medicine Malawi Cellular immunity Neutrophils Clinical Biochemistry wc_269 susceptibility Salmonella Interquartile range Immunology and Allergy Prospective Studies Spotlight Malaria Falciparum Respiratory Burst Immunity Cellular 3. Good health Child Preschool Salmonella Infections Female Disease Susceptibility Antibody qw_520 Microbiology (medical) Blood Bactericidal Activity Salmonella Vaccines qw_568 Immunology malaria Biology 03 medical and health sciences children Immunity parasitic diseases medicine Humans Infant Plasmodium falciparum Complement System Proteins medicine.disease biology.organism_classification immunity Immunity Humoral wc_750 030104 developmental biology qx_135 Bacteremia Humoral immunity biology.protein Clinical Immunology ws_440 Malaria |
| Zdroj: | CLINICAL AND VACCINE IMMUNOLOGY Clinical and Vaccine Immunology : CVI |
| ISSN: | 1556-6811 |
| Popis: | Invasive nontyphoidal Salmonella (iNTS) infections are commonly associated with Plasmodium falciparum infections, but the immunologic basis for this linkage is poorly understood. We hypothesized that P. falciparum infection compromises the humoral and cellular immunity of the host to NTS, which increases the susceptibility of the host to iNTS infection. We prospectively recruited children aged between 6 and 60 months at a Community Health Centre in Blantyre, Malawi, and allocated them to the following groups; febrile with uncomplicated malaria, febrile malaria negative, and nonfebrile malaria negative. Levels of Salmonella enterica serovar Typhimurium-specific serum bactericidal activity (SBA) and whole-blood bactericidal activity (WBBA), complement C3 deposition, and neutrophil respiratory burst activity (NRBA) were measured. Levels of SBA with respect to S . Typhimurium were reduced in febrile P. falciparum -infected children (median, −0.20 log10 [interquartile range {IQR}, −1.85, 0.32]) compared to nonfebrile malaria-negative children (median, −1.42 log10 [IQR, −2.0, −0.47], P = 0.052). In relation to SBA, C3 deposition on S . Typhimurium was significantly reduced in febrile P. falciparum -infected children (median, 7.5% [IQR, 4.1, 15.0]) compared to nonfebrile malaria-negative children (median, 29% [IQR, 11.8, 48.0], P = 0.048). WBBA with respect to S . Typhimurium was significantly reduced in febrile P. falciparum -infected children (median, 0.25 log10 [IQR, −0.73, 1.13], P = 0.0001) compared to nonfebrile malaria-negative children (median, −1.0 log10 [IQR, −1.68, −0.16]). In relation to WBBA, S . Typhimurium-specific NRBA was reduced in febrile P. falciparum -infected children (median, 8.8% [IQR, 3.7, 20], P = 0.0001) compared to nonfebrile malaria-negative children (median, 40.5% [IQR, 33, 65.8]). P. falciparum infection impairs humoral and cellular immunity to S . Typhimurium in children during malaria episodes, which may explain the increased risk of iNTS observed in children from settings of malaria endemicity. The mechanisms underlying humoral immunity impairment are incompletely understood and should be explored further. |
| Databáze: | OpenAIRE |
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