Rheumatoid arthritis in Poland and Lithuania: different clinical course and HLA associations despite similar genetic background
| Autor: | J. Pazdur, E Kubasiewicz, A Venalis, E Kaminska, A Smerdel, Rafał Płoski, P Sliwinska, K Valiukiene, O Førre, Vaidutis Kučinskas, I Butrimiene, E. Jastrzebska, J Jaworski, A Kozakiewicz |
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| Rok vydání: | 2004 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Letter Immunology Severity of Illness Index General Biochemistry Genetics and Molecular Biology Disease course Arthritis Rheumatoid Rheumatology Internal medicine Severity of illness Immunology and Allergy Medicine Humans Genetic Predisposition to Disease Recent onset business.industry Clinical course Lithuania Lithuanian HLA-DR Antigens Hla association Middle Aged medicine.disease language.human_language Clinical Practice Genetics Population Rheumatoid arthritis language Female Poland business HLA-DRB1 Chains |
| Zdroj: | Annals of the rheumatic diseases. 64(1) |
| ISSN: | 0003-4967 |
| Popis: | A recognised feature of rheumatoid arthritis (RA) is its clinical heterogeneity, which may be caused by HLA factors. This theory is supported by observations that relatively severe and mild RA are associated with, respectively, DRB1*041 and DRB1*01.2–4 Further, comparisons between populations show that the disease course in the Mediterranean is milder than in northern Europe,5–8 correlating with a higher frequency of DRB1*01 and lower frequency of DRB1*04 in the former than in the latter region.6,7,9 Poland and Lithuania are neighbouring central European countries. During clinical practice we noted that RA was less severe in Lithuanian than in Polish patients. To test this observation we prospectively analysed 24 Polish and 20 Lithuanian randomly recruited patients with recent onset RA … |
| Databáze: | OpenAIRE |
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