Scaffolds for the repair of bone defects in clinical studies: a systematic review
| Autor: | Linghua Ding, Tang Zhiming, Jingtang Li, Shi-Lang Xiong, Shi-Wei Liu, Liao Xingen, Jian-Hua Zeng, Long Xiong, Peng Qiu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
lcsh:Diseases of the musculoskeletal system Bone Regeneration 02 engineering and technology Bone healing Review 03 medical and health sciences Clinical lcsh:Orthopedic surgery Osteogenesis Medicine Animals Humans Orthopedics and Sports Medicine Bone regeneration Scaffolds Clinical Trials as Topic Wound Healing Tissue Engineering Tissue Scaffolds business.industry 021001 nanoscience & nanotechnology Bone defect lcsh:RD701-811 030104 developmental biology Search terms Inclusion and exclusion criteria Surgery lcsh:RC925-935 Bone Diseases 0210 nano-technology business Biomedical engineering |
| Zdroj: | Journal of Orthopaedic Surgery and Research Journal of Orthopaedic Surgery and Research, Vol 13, Iss 1, Pp 1-14 (2018) |
| ISSN: | 1749-799X |
| Popis: | Background This systematic review aims to summarize the clinical studies on the use of scaffolds in the repair of bony defects. Methods The relevant articles were searched through PubMed database. The following keywords and search terms were used: “scaffolds,” “patient,” “clinic,” “bone repair,” “bone regeneration,” “repairing bone defect,” “repair of bone,” “osteanagenesis,” “osteanaphysis,” and “osteoanagenesis.” The articles were screened according to inclusion and exclusion criteria, performed by two reviewers. Results A total of 373 articles were obtained using PubMed database. After screening, 20 articles were identified as relevant for the purpose of this systematic review. We collected the data of biological scaffolds and synthetic scaffolds. There are eight clinical studies of biological scaffolds included collagen, gelatin, and cellular scaffolds for bone healing. In addition, 12 clinical studies of synthetic scaffolds on HAp, TCP, bonelike, and their complex scaffolds for repairing bone defects were involved in this systematic review. Conclusions There are a lot of clinical evidences showed that application of scaffolds had a good ability to facilitate bone repair and osteogenesis. However, the ideal and reliable guidelines are insufficiently applied and the number and quality of studies in this field remain to be improved. |
| Databáze: | OpenAIRE |
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