Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis
| Autor: | Lars P. Ryder, Per Platz, Carsten Heilmann, Bodil K. Jakobsen, Niels Ødum, Arne Svejgaard, Jens J. Hyldig-Nielsen, Johannes Friis, F K Pedersen, Niels Morling |
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| Rok vydání: | 2008 |
| Předmět: |
Male
HLA-DP Antigens Linkage disequilibrium Denmark Lymphocyte Immunology Disease Human leukocyte antigen HLA-DR5 Antigen Biochemistry Antigen Genetics medicine Humans Immunology and Allergy Typing Child HLA-DR Serological Subtypes HLA-D Antigens business.industry Histocompatibility Antigens Class II Infant HLA-DR Antigens General Medicine medicine.disease Arthritis Juvenile medicine.anatomical_structure Child Preschool Relative risk Female Polyarthritis business |
| Zdroj: | University of Copenhagen |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.1986.tb00490.x |
| Popis: | Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen. |
| Databáze: | OpenAIRE |
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