Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: novel inhibitors of COX-2

Autor:	Charles L. Cywin, Diane Thome, Lazer Edward S, A. G. Graham, Sorcek Ronald J, L. Churchill, Genus J. Possanza
Rok vydání:	1999
Předmět:	Stereochemistry Clinical Biochemistry Pharmaceutical Science Carrageenan Biochemistry Chemical synthesis Sulfone chemistry.chemical_compound Structure-Activity Relationship Oral administration In vivo Microsomes Drug Discovery Animals Edema Cyclooxygenase Inhibitors Isoquinoline Molecular Biology chemistry.chemical_classification Sulfonyl biology Cyclooxygenase 2 Inhibitors Molecular Structure Chemistry Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Membrane Proteins Isoquinolines Rats Isoenzymes Kinetics Enzyme Enzyme inhibitor Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases biology.protein Cyclooxygenase 1 Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 8(10)
ISSN:	0960-894X
Popis:	A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase-2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the carrageenan-induced paw edema model in rats upon oral administration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cd313b3ca6af5229d7cbce67098888 https://pubmed.ncbi.nlm.nih.gov/9871731 Zobrazit plný text záznamu Full Text from ScienceDirect