Quantification of renal blood flow with contrast-enhanced ultrasound
| Autor: | Elizabeth Le, Jian Ping Bin, Kevin Wei, Jerrel Thorpe, Sanjiv Kaul, Matthew Coggins |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Dopamine Sulfur Hexafluoride Contrast Media Blood volume 030204 cardiovascular system & hematology PAH clearance Kidney Renal Artery Obstruction Renal artery stenosis Renal Circulation 030218 nuclear medicine & medical imaging 03 medical and health sciences Dogs 0302 clinical medicine medicine.artery Image Processing Computer-Assisted medicine Animals Renal artery Phospholipids Ultrasonography Observer Variation Blood Volume business.industry Blood flow medicine.disease Surgery medicine.anatomical_structure Renal blood flow Nuclear medicine business Cardiology and Cardiovascular Medicine Blood Flow Velocity Contrast-enhanced ultrasound |
| Zdroj: | Journal of the American College of Cardiology. 37(4):1135-1140 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/s0735-1097(00)01210-9 |
| Popis: | OBJECTIVES The goal of this study was to determine the ability of contrast-enhanced ultrasound (CEU) to quantify renal tissue perfusion. BACKGROUND The kinetics of tracers used to assess renal perfusion are often complicated by countercurrent exchange, tubular transport or glomerular filtration. We hypothesized that, because gas-filled microbubbles are pure intravascular tracers with a rheology similar to that of red blood cells, CEU could be used to quantify renal tissue perfusion. METHODS During a continuous venous infusion of microbubbles (SonoVue), regional renal perfusion was quantified in nine dogs using CEU by destroying microbubbles and measuring their tissue replenishment with intermittent harmonic imaging. Both renal blood volume fraction and microbubble velocity were derived from pulsing-interval versus video-intensity plots. The product of the two was used to calculate renal nutrient blood flow. Renal arterial blood flow was independently measured with ultrasonic flow probes placed directly on the renal artery and was increased using dopamine and decreased by placement of a renal artery stenosis. RESULTS An excellent correlation was found between cortical nutrient blood flow using microbubbles and ultrasonic flow probe-derived renal blood flow (r = 0.82, p < 0.001) over a wide range (2.5 fold) of flows. CONCLUSIONS Ultrasound examination during microbubble infusion can be used to quantify total organ as well as regional nutrient blood flow to the kidney. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|