Effect of clopidogrel on naproxen-induced gastrointestinal blood loss in healthy volunteers
| Autor: | Jozef Arnout, M Depre, Alfons Verbruggen, H Vanbilloen, P Vanhove, P. J. De Schepper, A. Van Hecken, R Cariou, Kathleen Wynants |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Naproxen Bleeding Time Ticlopidine Platelet Aggregation Placebo law.invention Randomized controlled trial Blood loss Double-Blind Method Bleeding time law medicine Humans Pharmacology (medical) Drug Interactions medicine.diagnostic_test business.industry Anti-Inflammatory Agents Non-Steroidal Clopidogrel Anesthesia Occult Blood Platelet aggregation inhibitor business Gastrointestinal Hemorrhage Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Drug metabolism and drug interactions. 14(3) |
| ISSN: | 0792-5077 |
| Popis: | The effect of clopidogrel, a potent inhibitor of platelet aggregation, on naproxen-induced faecal blood loss was investigated in 30 healthy volunteers in a randomized, double-blind, placebo-controlled, two parallel treatment groups study. All subjects first received naproxen 250 mg b.i.d. during 7 days, after which they were randomly allocated to additionally receive either clopidogrel 75 mg once daily (n = 15) or matching placebo (n = 15) for 11 days. Faecal blood loss was measured by the 51Cr-labelled erythrocyte method during the last four days of each of the four study periods, i.e. baseline, treatment with naproxen alone, combined treatment and wash-out. Mean daily faecal blood loss was below 0.5 ml/day during the baseline period in both treatment groups and increased during treatment with naproxen alone to (mean +/- SD) 1.14 +/- 0.58 ml/day in the naproxen + placebo group and to 1.93 +/- 1.51 ml/day in the naproxen + clopidogrel group. Addition of clopidogrel to naproxen treatment was associated with an increase of the mean daily blood loss to 6.83 +/- 9.32 ml/day, which was statistically significantly higher than 1.75 +/- 1.40 ml/day observed during treatment with naproxen + placebo. During the wash-out period, mean daily blood loss decreased to 0.98 +/- 0.51 ml/day in the naproxen + placebo group and to 1.07 +/- 0.46 ml/day in the naproxen + clopidogrel group. Based on these results, it can be concluded that clopidogrel increases naproxen-induced gastrointestinal blood loss in healthy volunteers. Caution should therefore be called for when these drugs are coadministered. |
| Databáze: | OpenAIRE |
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