Restriction Fragment Length Polymorphisms of Three Collagen Genes in Russians and Buryats
| Autor: | B.P. Sokolov, V.V. Dzemelinski, V.N. Kalinin |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Genetics
Connective tissue Population genetics Biology Moscow White People Phenotype medicine.anatomical_structure Asian People Gene Frequency Polymorphism (computer science) parasitic diseases medicine Humans Collagen Allele Restriction fragment length polymorphism Gene Allele frequency Alleles Polymorphism Restriction Fragment Length Genetics (clinical) |
| Zdroj: | Human Heredity. 41:57-60 |
| ISSN: | 1423-0062 0001-5652 |
| DOI: | 10.1159/000153975 |
| Popis: | The restriction fragment length polymorphisms (RFLPs) of 3 collagen genes have been studied in two USSR populations. Four high-frequency alleles, also reported in other populations, were observed. The frequencies of alleles for the polymorphic sites MspI and EcoRI of the COL1A2 gene, HindIII of the COL2A1 gene and EcoRI of the COL3A1 gene were found to be 0.836, 0.398, 0.447 and 0.786, respectively, in Russians from Moscow (Caucasians), and 0.883, 0.519, 0.648 and 0.809, respectively, in Buryats from the Baikal region (Mongoloids). The RFLPs showed a fair agreement with the Hardy-Weinberg equilibrium. The frequencies were compared with those of other populations. |
| Databáze: | OpenAIRE |
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