Additional file 1: of Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance

Autor: Stringer, Jessica, Forster, Samuel, Zhipeng Qu, Prokopuk, Lexie, O’Bryan, Moira, Gardner, David, White, Stefan, Adelson, David, Western, Patrick
Rok vydání: 2018
DOI: 10.6084/m9.figshare.7116200
Popis: Figure S1. Survival and fertility of Eedhypo/hypo animals. Figure S2. Foetal somatic and germ cells reached expected developmental milestones and expressed endogenous germ cell markers in Eedhypo/hypo males. Figure S3. H3K27me3 was enriched at known PRC2 target genes in Eedhypo/hypo compared to Eedwt/wt germ cells. Figure S4. Read counts and technical consistency between RNAseq samples generated from (Aâ B) E15.5 Eedwt/wt and Eedhypo/hypo male germ cells and (C) D8-cell offspring from Eedwt/wt and Eedhypo/hypo males. Figure S5. Transcriptional analyses of E8.5 offspring produced by Eedhypo/hypo, Eedhypo/wt and Eedwt/wt male mice mated to wild-type females. Figure S6. Neonatal weight and size are not different in offspring of Eedhypo/wt Eedhypo/hypo and males. Figure S7. Active Motif Modified Histone Array analysis of H3K27me3 ChIP antibody. (PDF 15192 kb)
Databáze: OpenAIRE