Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States
| Autor: | Tamas L. Horvath, Zoltan Barany, István János Tóth, Gergely Jocsak, Attila Zsarnovszky, Tibor Bartha, Laszlo V. Frenyo, Dávid Sándor Kiss |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Food intake Feeding state Gonadectomy Hypothalamus Biology Satiety Response Lateralization of brain function Functional Laterality 03 medical and health sciences Regulation of homeostasis 0302 clinical medicine Melanocortin system Internal medicine Male rats medicine Animals Homeostasis Castration Right hemisphere Rats Wistar Hypothalamic asymmetry Neurons Reproduction Obstetrics and Gynecology Functional lateralization Mitochondria Rats 030104 developmental biology Endocrinology Mitochondrial metabolism Original Article Functional asymmetry 030217 neurology & neurosurgery |
| Zdroj: | Reproductive Sciences |
| ISSN: | 1933-7205 1933-7191 |
| Popis: | The hypothalamus is the main regulatory center of many homeostatic processes, such as reproduction, food intake, and sleep-wake behavior. Recent findings show that there is a strongly interdependent side-linked localization of hypothalamic functions between the left and right hemispheres. The goal of the present study was to trace functional asymmetry of the hypothalamus related to the regulation of food intake and reproduction, in male rodents. Subjects were examined through measurements of mitochondrial metabolism ex vivo. Impact of gonadectomy and scheduled feeding was tested on the modulation of hypothalamic metabolic asymmetry. Results show that in male rats, functional lateralization of the hypothalamus can be attributed to the satiety state rather than to reproductive control. Fasting caused left-sided metabolic dominance, while satiety was linked to the right hemisphere; trends and direction in sided dominance gradually followed the changes in satiety state. Our findings revealed satiety state-dependent metabolic differences between the two hypothalamic hemispheres. It is therefore concluded that, at least in male rats, the hypothalamic hemispheres control the satiety state-related functions in an asymmetric manner. |
| Databáze: | OpenAIRE |
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