Positive association of serum interleukin-1β and CRH levels in women with pre-term labor
| Autor: | K Papadias, A. Kountouris, Georgios Creatsas, Nikolaos Vitoratos, George Mastorakos |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Corticotropin-Releasing Hormone Placenta Endocrinology Diabetes and Metabolism Interleukin-1beta Group A Group B Corticotropin-releasing hormone Obstetric Labor Premature Endocrinology Pregnancy Internal medicine Humans Medicine Labor Obstetric business.industry medicine.disease Pathophysiology medicine.anatomical_structure Gestation Female business Hormone |
| Zdroj: | Journal of Endocrinological Investigation. 30:35-40 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03347393 |
| Popis: | Objective: The aim of this study was to investigate the hypothesis that interleukin-1β (IL-1β) might be involved in the increase of the circulating levels of placental-derived CRH leading to the initiation of pre-term labor. Subjects and methods: Forty-eight primigravidae with a singleton viable pregnancy between 28 and 34 weeks of gestation were studied. The subjects were divided in two groups: group A consisted of 30 pregnant women (mean age±SD; 22±1.1 yr old) presented with preterm labor (mean gestational age±SD; 30.6±2.3 weeks) and group B consisted of 18 pregnant women (24±2.6 yr old) with normal pregnancies (29.8±3.1 weeks). CRH and IL-1β levels were measured in blood specimens collected from all the study subjects on admission. Results: Women of group A presented significantly higher serum CRH levels (mean±SE; 1.18±1.83 ng/ml) compared to those of group B (0.48±0.67 ng/ml) (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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