Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells
| Autor: | Julie Randolph-Habecker, Veronika Groh, Max S. Topp, Stanley R. Riddell, Thomas Spies, Rebecca Rhinehart |
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| Rok vydání: | 2001 |
| Předmět: |
Receptors
Antigen T-Cell alpha-beta T cell Immunology Antigen presentation Cytomegalovirus chemical and pharmacologic phenomena CD8-Positive T-Lymphocytes Biology Lymphocyte Activation medicine Humans Immunology and Allergy Cytotoxic T cell Endothelium IL-2 receptor Receptors Immunologic Antigen-presenting cell Cells Cultured Histocompatibility Antigens Class I hemic and immune systems Fibroblasts Cytotoxicity Tests Immunologic Natural killer T cell NKG2D Cell biology medicine.anatomical_structure NK Cell Lectin-Like Receptor Subfamily K Cytomegalovirus Infections Interleukin-2 Receptors Natural Killer Cell Lung Diseases Interstitial CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Nature Immunology. 2:255-260 |
| ISSN: | 1529-2916 1529-2908 |
| DOI: | 10.1038/85321 |
| Popis: | NKG2D is an activating receptor that stimulates innate immune responses by natural killer cells upon engagement by MIC ligands, which are induced by cellular stress. Because NKG2D is also present on most CD8alphabeta T cells, it may modulate antigen-specific T cell responses, depending on whether MIC molecules--distant homologs of major histocompatibility complex (MHC) class I with no function in antigen presentation--are induced on the surface of pathogen-infected cells. We found that infection by cytomegalovirus (CMV) resulted in substantial increases in MIC on cultured fibroblast and endothelial cells and was associated with induced MIC expression in interstitial pneumonia. MIC engagement of NKG2D potently augmented T cell antigen receptor (TCR)-dependent cytolytic and cytokine responses by CMV-specific CD28- CD8alphabeta T cells. This function overcame viral interference with MHC class I antigen presentation. Combined triggering of TCR-CD3 complexes and NKG2D induced interleukin 2 production and T cell proliferation. Thus NKG2D functioned as a costimulatory receptor that can substitute for CD28. |
| Databáze: | OpenAIRE |
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