Protective Effect of a Synthetic Polynucleotide Complex (Poly I: C) on Ocular Lesions Produced by Trachoma Agent in Rabbits
| Autor: | J. O. Oh, H. B. Ostler, Julius Schachter |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Pathology
medicine.medical_specialty genetic structures Antimicrobial Agents and Chemotherapy business.industry Immunology Idoxuridine Pharmacology medicine.disease Microbiology eye diseases In vitro Keratitis Infectious Diseases medicine.anatomical_structure Trachoma Interferon Cornea Corneal neovascularization medicine Parasitology Inducer sense organs business medicine.drug |
| Zdroj: | Infection and Immunity. 1:566-573 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.1.6.566-573.1970 |
| Popis: | Live trachoma agent (TE55) injected into the anterior chamber of the rabbit eye produced the following agent-specific ocular lesions: corneal opacity, corneal neovascularization, and iritis. Three intravenous injections of 1 mg of a potent interferon (IF) inducer, polyriboinosinic acid-polyribocytidylic acid complex (poly I:C), markedly suppressed the ocular lesions produced by the trachoma agent but failed to inhibit the growth of the agent in the ocular tissues. Furthermore, a single intravenous injection of 1 mg of polyriboinosinic acid or of polyribocytidylic acid was also protective, although each failed to induce any detectable circulating IF. These results indicate that a factor or factors other than IF may play a role in the suppression of the ocular lesions produced by trachoma agent in poly I:C-injected rabbits. |
| Databáze: | OpenAIRE |
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