International external quality assessment for measurements of direct oral anticoagulants: results and recommendations
| Autor: | Piet Meijer, Martine J Hollestelle |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Quality Assurance Health Care Administration Oral Dabigatran 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Edoxaban External quality assessment medicine Humans Intensive care medicine Clinical decision Rivaroxaban business.industry Anticoagulants Hematology chemistry 030220 oncology & carcinogenesis Practice Guidelines as Topic Apixaban Female business 030215 immunology medicine.drug |
| Zdroj: | British journal of haematologyReferences. 188(3) |
| ISSN: | 1365-2141 |
| Popis: | There is limited information regarding the performance of tests for direct oral anticoagulants (DOACs). To generate more knowledge, the accuracy of DOAC tests were evaluated using external quality assessment data from multiple years. This data demonstrated a good correlation for the tests with a small overall interlaboratory variability (10% for dabigatran, rivaroxaban and apixaban and 12% for edoxaban). The greatest differences between the various reagents were observed for rivaroxaban, especially for concentrations below 100 ng/ml. In conclusion, the results show overall reliable DOAC levels with some differences between reagent groups. Important finding: clinical decision criteria could be affected by the choice of reagent. |
| Databáze: | OpenAIRE |
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