Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium
| Autor: | Roni T. Falk, Walter C. Willett, Elio Riboli, Rosie Cooke, George Gkiokas, Michael B. Cook, Anthony J. Swerdlow, Pascal Guénel, Louise A. Brinton, Kenneth C. Johnson, Marianne Ewertz, Mia M. Gaudet, David B. Thomas, Karin B. Michels, Dominick Parisi, Jay H. Lubin, John T. Casagrande, Piet A. van den Brandt, Eleni Petridou, Elsebeth Lynge, Håkan Olsson, Carlo La Vecchia, Valerie McCormack, Howard D. Sesso, Stephen K. Van Den Eeden, Laurel A. Habel, Laurence N. Kolonel, Eva Negri, Ann W. Hsing, Susan M. Gapstur |
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| Přispěvatelé: | M. B. Cook, P. Guénel, S. M. Gapstur, P. A. Van Den Brandt, K. B. Michel, J. T. Casagrande, R. Cooke, S. K. Van Den Eeden, M. Ewertz, R. T. Falk, M. M. Gaudet, G. Gkioka, L. A. Habel, A. W. Hsing, K. Johnson, L. N. Kolonel, C. La Vecchia, E. Lynge, J. H. Lubin, V. A. Mccormack, E. Negri, H. Olsson, D. Parisi, E. T. Petridou, E. Riboli, H. D. Sesso, A. Swerdlow, D. B. Thoma, W. C. Willett, L. A. Brinton, RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology ACTIVE SMOKING Epidemiology Alcohol Drinking/adverse effects Cohort Studies Risk Factors Smoking/adverse effects Tobacco/adverse effects Smoking pipe education.field_of_study Smoking MEN United States/epidemiology Chewing tobacco Male breast cancer Cohort MENSTRUAL-CYCLE Case-Control Studie Breast Neoplasm Human Cohort study United State medicine.medical_specialty Alcohol Drinking UNITED-STATES Article Breast Neoplasms Male Internal medicine Tobacco BASE-LINE CHARACTERISTICS medicine Humans Snuff education Gynecology business.industry Risk Factor Case-control study Odds ratio medicine.disease MODELING TOTAL EXPOSURE United States BODY-MASS INDEX Case-Control Studies RISK-FACTORS Breast Neoplasms Male/epidemiology CIGARETTE-SMOKING Cohort Studie business FOLLOW-UP |
| Zdroj: | Cook, M B, Guenel, P, Gapstur, S M, van den Brandt, P A, Michels, K B, Casagrande, J T, Cooke, R, Van Den Eeden, S K, Ewertz, M, Falk, R T, Gaudet, M M, Gkiokas, G, Habel, L A, Hsing, A W, Johnson, K, Kolonel, L N, La Vecchia, C, Lynge, E, Lubin, J H, McCormack, V A, Negri, E, Olsson, H, Parisi, D, Petridou, E T, Riboli, E, Sesso, H D, Swerdlow, A, Thomas, D B, Willett, W C & Brinton, L A 2015, ' Tobacco and Alcohol in Relation to Male Breast Cancer : An Analysis of the Male Breast Cancer Pooling Project Consortium ', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol. 24, no. 3, pp. 520-531 . https://doi.org/10.1158/1055-9965.EPI-14-1009 Cancer Epidemiology Biomarkers & Prevention, 24(3), 520-531. American Association for Cancer Research Inc. |
| ISSN: | 1055-9965 |
| DOI: | 10.1158/1055-9965.epi-14-1009 |
| Popis: | Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined. Methods: The Male Breast Cancer Pooling Project consortium provided 2,378 cases and 51,959 controls for analysis from 10 case–control and 10 cohort studies. Individual participant data were harmonized and pooled. Unconditional logistic regression was used to estimate study design–specific (case–control/cohort) ORs and 95% confidence intervals (CI), which were then combined using fixed-effects meta-analysis. Results: Cigarette smoking status, smoking pack-years, duration, intensity, and age at initiation were not associated with male breast cancer risk. Relations with cigar and pipe smoking, tobacco chewing, and snuff use were also null. Recent alcohol consumption and average grams of alcohol consumed per day were also not associated with risk; only one subanalysis of very high recent alcohol consumption (>60 g/day) was tentatively associated with male breast cancer (ORunexposed referent = 1.29; 95% CI, 0.97–1.71; OR>0– Conclusions: In this analysis of the Male Breast Cancer Pooling Project, we found little evidence that tobacco and alcohol exposures were associated with risk of male breast cancer. Impact: Tobacco and alcohol do not appear to be carcinogenic for male breast cancer. Future studies should aim to assess these exposures in relation to subtypes of male breast cancer. Cancer Epidemiol Biomarkers Prev; 24(3); 520–31. ©2014 AACR. |
| Databáze: | OpenAIRE |
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