Collectin surfactant protein D binds antibodies and interlinks innate and adaptive immune systems
| Autor: | Nades Palaniyar, Jeya Nadesalingam, Kenneth B.M. Reid |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adaptive immunity
Biophysics Immunoglobulins Collectin Biology Biochemistry Immunoglobulin Fab Fragments Mice 03 medical and health sciences 0302 clinical medicine Immune system Phagocytosis Antigen Structural Biology Genetics Animals Humans Macrophage Molecular Biology 030304 developmental biology Innate immunity 0303 health sciences Innate immune system Surfactant protein D Cell Biology Antibody recognition Pulmonary Surfactant-Associated Protein D Acquired immune system Molecular biology Immunity Innate Collectins Immunoglobulin Fc Fragments 3. Good health Cell biology biology.protein Antibody Immune system evolution 030215 immunology |
| Zdroj: | FEBS Letters. 579:4449-4453 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2005.07.012 |
| Popis: | Innate immune collectins, such as surfactant protein D (SP-D), contain fibrillar collagen-like regions and globular carbohydrate-recognition domains (CRDs). SP-D recognizes carbohydrate arrays present on microbial surfaces via its CRDs, agglutinates microbes and enhances their phagocytosis. In contrast, adaptive immune proteins such as immunoglobulins (Igs) recognize pathogens via binding to specific antigens. Here we show that: SP-D binds various classes of immunoglobins, including IgG, IgM, IgE and secretory IgA, but not serum IgA; the globular domains of SP-D bind both the Fab and Fc domains of IgG; SP-D recognizes IgG via calcium-dependent protein–protein interactions, aggregates IgG-coated beads and enhances their phagocytosis by murine macrophage RAW 264.7 cells. Therefore, we propose that SP-D effectively interlinks innate and adaptive immune systems. |
| Databáze: | OpenAIRE |
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