Prognostic Value of Preoperative Body Mass Index for Diabetic Patients with Non-metastasis Gastric Cancer: A Single Center Experience
| Autor: | Shu Chen, Zaisheng Ye, Yunqing Xie, Yi Wang, Shenghong Wei, Qiuhong Zheng, Luchuan Chen, Zhitao Lin, Yi Zeng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Survival rate RD1-811 medicine.medical_treatment Single Center Gastroenterology Body Mass Index BMI Gastrectomy Stomach Neoplasms Surgical oncology Internal medicine Type 2 diabetes mellitus medicine Humans Stage (cooking) Neoplasm Staging Retrospective Studies Proportional hazards model business.industry Cancer General Medicine Prognosis medicine.disease Surgery Diabetes Mellitus Type 2 Lymphadenectomy business Gastric cancer Body mass index X-tile Research Article |
| Zdroj: | BMC Surgery, Vol 21, Iss 1, Pp 1-7 (2021) BMC Surgery |
| Popis: | Aim This study was designed to investigate the prognostic effect of preoperative body mass index (BMI) for Type 2 diabetes mellitus (T2DM) patients with non-metastasis gastric cancer (GC) who underwent D2 gastrectomy. Methods T2DM patients with pT1–4bN0–3bM0 GC were retrospectively collected in Department of Gastrointestinal Surgical Oncology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital from January, 2000 to December, 2010. These patients underwent D2 radical resection of the stomach combined with regional lymphadenectomy. Chi-square test was used to analyze unordered categorical variables and ranked data, followed by Kaplan–Meier analysis as well as Cox regression models to detect risk factors for survival outcomes. In addition, the cut-off point was determined by the X-tile program. All analyses were carried out using survival package of R and SPSS Software. Results A total of 302 T2DM patients with pT1–4bN0–3bM0 GC were collected and analyzed. The cut-off points of BMI, identified by the X-tile program, was 19 kg/m2. Patients with low BMI (2) had a higher percentage of advanced T stage (T4a and T4b), more advanced TNM stage (stage IIIA, IIIB and IIIC), and more elevated level of serum carcinoembryonic antigen (CEA), compared to those with high BMI (> 19 kg/m2) (all P P C stage (OR = 3.101), N3b stage (OR = 3.113) were the most important prognostic indicators, followed by pretreatment BMI (OR = 2.136). Conclusion Low preoperative BMI (2) was a poor prognostic marker for T2DM patients with pT1–4bN0–3bM0 GC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|