Risk Factors and Clinical Phenotypes Associated with Severity in Patients with COVID-19 in Northeast Mexico
| Autor: | Elida Moran Guel, Maritza Argelia Macías Corral, Melisa Alejandra Muñoz-Hernández, Francisco Javier García-Alvarado, Marisela del Rocío González-Martínez, Héctor Delgado-Aguirre |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging Disease Overweight Microbiology Cohort Studies Fibrin Fibrinogen Degradation Products Sex Factors Risk Factors Virology Internal medicine Diabetes mellitus medicine Humans Prospective Studies Mexico Aged business.industry SARS-CoV-2 COVID-19 Retrospective cohort study Odds ratio Middle Aged medicine.disease Obesity Confidence interval Infectious Diseases Phenotype Diabetes Mellitus Type 2 Female medicine.symptom business Cohort study |
| Zdroj: | Vector borne and zoonotic diseases (Larchmont, N.Y.). 21(9) |
| ISSN: | 1557-7759 |
| Popis: | Objective: The aim of this study is to describe the main clinical phenotypes, laboratory findings, and severity of coronavirus disease 2019 (COVID-19) in patients hospitalized at the High Specialty Medical Unit # 71 of the Mexican Social Security Institute. Methods: Prospective observational cohort study with a total of 105 patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at the High Specialty Medical Unit # 71 (Torreon, Coahuila, Mexico), from May 15th to August 15th, 2020. The cases were confirmed to be COVID-19 positive through an RT-qPCR test. Clinical phenotypes and laboratory tests were evaluated to determine the degree of severity of the disease and the most frequent comorbidities. Results: The clinical characteristics of a total of 105 hospitalized patients (47 females and 58 males; median age being 52 years) with confirmed COVID-19 diagnoses were studied. The severity of the disease was classified as moderate grade (62.7%), severe grade (21.5%), and critical grade (15.6%). Among the most frequent underlying pathologies coexisted overweight (n = 75, 78.12%), obesity (n = 21, 21.87%), diabetes (n = 10, 9.52%), and hypertension (n = 6, 5.71%), some of these patients present more than one pathology. This association was found with diabetes (odds ratio [OR]: 1.42; 95% confidence interval [CI]: 1.23-1.97; p = 0.021) and high levels of D-dimer (OR: 1.01; 95% CI: 1.00-1.08; p = 0.001). Conclusion: In this retrospective cohort study of patients with COVID-19 from a specialty hospital in the northeast region of Mexico, it was observed that clinical phenotypes and D-dimer elevation were compatible with an inflammatory state by degree of severity; it was found that the hospitalized patients with underlying chronic medical conditions such as diabetes and elevated D-dimer levels were significantly associated with increased mortality from COVID-19. Age and sex (males) were two factors highly associated with mortality. |
| Databáze: | OpenAIRE |
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