The role of endogenous and exogenous DNA damage and mutagenesis
| Autor: | Roger A. Schultz, Lisa D. McDaniel, Errol C. Friedberg |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Genetics
DNA Repair DNA repair DNA damage Mutagenesis Endogeny DNA-Directed DNA Polymerase G2-M DNA damage checkpoint Biology DNA-Binding Proteins Genes cdc chemistry.chemical_compound Fanconi Anemia Bacteriocins chemistry Neoplasms Humans Exogenous DNA Rad51 Recombinase Gene DNA DNA Damage Developmental Biology |
| Zdroj: | Current Opinion in Genetics & Development. 14:5-10 |
| ISSN: | 0959-437X |
| Popis: | The field of DNA damage responsiveness in general, and the consequences of endogenous and exogenous base damage in DNA, in particular, has made new and exciting contributions to our increasing understanding of the initiation and progression of neoplasia in humans. This article presents some of the highlights in this area of investigation, with a particular emphasis on DNA repair, the tolerance of DNA damage and its contribution to mutagenesis, and DNA damage checkpoint regulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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