The Transformer database: biotransformation of xenobiotics
| Autor: | Mathias Dunkel, Robert Preissner, Janette Nickel, Saskia Preissner, Sarah C. Preissner, Michael F. Hoffmann |
|---|---|
| Přispěvatelé: | MDC Library |
| Rok vydání: | 2013 |
| Předmět: |
Drug
food.ingredient Protein Conformation media_common.quotation_subject 570 Life Sciences Biology computer.software_genre Grapefruit juice Xenobiotics 610 Medical Sciences Medicine chemistry.chemical_compound food Cytochrome P-450 Enzyme System Biotransformation Genetics Data Mining Humans Pharmacokinetics Prodrugs Transformer (machine learning model) media_common Internet Database Membrane Transport Proteins Cytochrome P450 Prodrug Enzymes VI. Genomic variation diseases and drugs chemistry Cardiovascular and Metabolic Diseases biology.protein Chemical Databases Xenobiotic computer Databases Chemical Drug metabolism |
| Zdroj: | Nucleic Acids Research Nucleic Acids Research 42 (1): D1113-D1117. |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gkt1246 |
| Popis: | As the number of prescribed drugs is constantly rising, drug-drug interactions are an important issue. The simultaneous administration of several drugs can cause severe adverse effects based on interactions with the same metabolizing enzyme(s). The Transformer database (http://bioinformatics.charite.de/transformer) contains integrated information on the three phases of biotransformation (modification, conjugation and excretion) of 3000 drugs and >350 relevant food ingredients (e.g. grapefruit juice) and herbs, which are catalyzed by 400 proteins. A total of 100 000 interactions were found through text mining and manual validation. The 3D structures of 200 relevant proteins are included. The database enables users to search for drugs with a visual display of known interactions with phase I (Cytochrome P450) and phase II enzymes, transporters, food and herbs. For each interaction, PubMed references are given. To detect mutual impairments of drugs, the drug-cocktail tool displays interactions between selected drugs. By choosing the indication for a drug, the tool offers suggestions for alternative medications to avoid metabolic conflicts. Drug interactions can also be visualized in an interactive network view. Additionally, prodrugs, including their mechanisms of activation, and further information on enzymes of biotransformation, including 3D models, can be viewed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|