Skeletal muscle ventricles: left ventricular apex to aorta configuration
| Autor: | Michael Colson, Robert Fietsam, Renato Ruggiero, Hidehiro Nakajima, Frank W. Mocek, Hisako O. Nakajima, Robert L. Hammond, Larry W. Stephenson, Gregory A. Thomas, Huiping Lu |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Pacemaker Artificial Heart Ventricles Diastole Hemodynamics Blood Pressure Ventricular Function Left Electrocardiography Dogs medicine.artery Internal medicine Medicine Animals Polytetrafluoroethylene Aorta Bioprosthesis business.industry Muscles Latissimus dorsi muscle Suture Techniques Skeletal muscle Stroke Volume Myocardial Contraction Apex (geometry) Blood Vessel Prosthesis Skeletal Muscle Ventricle Blood pressure medicine.anatomical_structure Anesthesia Heart Valve Prosthesis cardiovascular system Cardiology Surgery Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Annals of thoracic surgery. 55(1) |
| ISSN: | 0003-4975 |
| Popis: | Skeletal muscle ventricles (SMVs) were constructed from the latissimus dorsi muscle in 6 dogs. After 3 weeks of vascular delay followed by 6 weeks of 2-Hz continuous electrical conditioning, a valved conduit was placed between the left ventricular apex and the SMV and a second valved conduit, between the SMV and the aorta. The SMV was stimulated to contract during diastole at a 1:2 ratio with the heart. The SMV pumped 47% of the systemic blood flow initially (0.73 +/- 0.23 versus 1.54 +/- 0.42 L/min) and 40% after 3 hours. Skeletal muscle ventricle stimulation resulted in a 58% increase in mean diastolic pressure initially (52 +/- 9 to 82 +/- 11 mm Hg; p0.05) and a 73% increase (45 +/- 7 to 78 +/- 8 mm Hg) after 3 hours of continuous pumping. This was associated with a 68% increase in the endocardial viability ratio initially and a 63% increase at 3 hours. The systolic tension-time index decreased by 26% initially and 25% at 3 hours. This study indicates that the SMV configuration of left ventricular apex to aorta may be particularly suitable for left ventricular assist. |
| Databáze: | OpenAIRE |
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