C-reactive protein/albumin ratio is associated with lung function among children/adolescents with cystic fibrosis: a three-year longitudinal study
| Autor: | Emilia Addison Machado Moreira, Julia Salvan da Rosa, Daniela Barbieri Hauschild, Eliana Barbosa, Tânia Silvia Fröde, Yara Maria Franco Moreno, Norberto Ludwig-Neto, Anauã Franco Rosa, Julia Carvalho Ventura, Leticia C R Pereira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Longitudinal study medicine.medical_specialty Adolescent Interleukin-1beta Serum albumin lcsh:Medicine Cystic fibrosis C-reactive protein 03 medical and health sciences 0302 clinical medicine Nutritional status Interquartile range Internal medicine medicine Humans Outpatient clinic Longitudinal Studies Prospective Studies 030212 general & internal medicine Child Lung diseases Peroxidase biology Tumor Necrosis Factor-alpha business.industry lcsh:R General Medicine Odds ratio medicine.disease Confidence interval Respiratory Function Tests 030228 respiratory system biology.protein Female Inflammation Mediators business Biomarkers |
| Zdroj: | Sao Paulo Medical Journal v.136 n.1 2018 São Paulo medical journal Associação Paulista de Medicina instacron:APM São Paulo Medical Journal, Iss 0 (2017) Sao Paulo Medical Journal, Issue: ahead, Published: 18 DEC 2017 Sao Paulo Medical Journal, Volume: 136, Issue: 1, Pages: 29-36, Published: 18 DEC 2017 |
| Popis: | BACKGROUND: Chronic lung infections, inflammation and depletion of nutritional status are considered to be prognostic indicators of morbidity in patients with cystic fibrosis. The aim of this study was to investigate the association between inflammatory markers and lung function, nutritional status and morbidity among children/adolescents with cystic fibrosis. DESIGN AND SETTINGS: Prospective three-year longitudinal study conducted in an outpatient clinic in southern Brazil. METHODS: Children/adolescents aged 1-15 years with cystic fibrosis were enrolled. Nutritional status was determined from weight-to-length and body mass index-to-age z-scores and was classified as acceptable, at risk or nutritional failure. Tumor necrosis factor-α, interleukin-1β, myeloperoxidase, C-reactive protein and C-reactive protein/albumin ratio were analyzed. Lung function was evaluated based on the forced expiratory volume in the first second and morbidity according to the number of hospitalizations for pulmonary exacerbation and infections by Pseudomonas aeruginosa. Lung function, nutritional status and morbidity were the outcomes. Odds ratios and 95% confidence intervals were to evaluate the effect of baseline inflammatory markers on the clinical outcomes after three years of follow-up and p-values < 0.05 were considered significant. RESULTS: We evaluated 38 children/adolescents with cystic fibrosis: 55% female; median age (with interquartile range), 3.75 years (2.71-7.00). Children/adolescents with high C-reactive protein/albumin ratio at baseline had odds of 18 (P = 0.018) of presenting forced expiratory volume in the first second ≤ 70% after three years. The other inflammatory markers were not associated with the outcomes. CONCLUSION: C-reactive protein/albumin ratio was associated with forced expiratory volume in the first second ≤ 70% after three years. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|