Does empiric superovulation improve fecundity in healthy women undergoing therapeutic donor insemination without a male partner?
| Autor: | Audrey O. Chang, Leah Hawkins Bressler, Sarah M. Moustafa, Brittany Papworth, Jennifer E. Mersereau |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Infertility Donor insemination medicine.medical_specialty Superovulation Empirical Research Cohort Studies Young Adult medicine Humans Insemination Artificial Retrospective Studies Pregnancy business.industry Obstetrics Incidence (epidemiology) Letrozole Obstetrics and Gynecology Retrospective cohort study Fecundity medicine.disease Healthy Volunteers Tissue Donors Fertility Reproductive Medicine Gestation Female business medicine.drug |
| Zdroj: | Fertility and Sterility. 113:114-120 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2019.08.101 |
| Popis: | Objective To evaluate whether superovulation improves fecundity in women undergoing therapeutic donor insemination (TDI). Design Retrospective cohort study. Setting University-affiliated fertility clinic. Patient(s) Healthy women aged 23–45 years with no history of or risk factors for infertility who underwent 152 medicated and 104 unmedicated TDI cycles from 2013 to 2018. Intervention Unmedicated TDI versus use of medication in a TDI cycle (clomiphene citrate or letrozole). Main Outcome Measure(s) Cumulative probability of pregnancy in six TDI cycles. Result(s) In adjusted all-cycle analysis, medicated TDI cycles were less likely to result in pregnancy compared with unmedicated cycles. The incidence of twins was 23% in the medicated group and 0% in the unmedicated group. Medicated cycles were less likely to result in pregnancy in women younger than 40 years or with an antimullerian hormone (AMH) level >1.2. After three cycles not resulting in pregnancy, the only women who conceived were those who crossed over from an unmedicated to a medicated cycle (12% vs. 0%). Conclusion(s) Patients undergoing unmedicated TDI cycles had higher fecundity and no incidence of twin gestations. Older women, those with low AMH, and those who fail to conceive after three unmedicated cycles may benefit from medication. |
| Databáze: | OpenAIRE |
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