Changes in Visceral Adiposity, Subcutaneous Adiposity, and Sex Hormones in the Diabetes Prevention Program

Autor: Sherita Hill Golden, Christine Darwin, Catherine Kim, George A. Bray, Costas A. Christophi, Dana Dabelea, Elizabeth Barrett-Connor, Edward J. Boyko, Xavier Pi-Sunyer, Rita R. Kalyani, Swaytha Yalamanchi
Rok vydání: 2017
Předmět:
Blood Glucose
Male
0301 basic medicine
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Adipose tissue
Overweight
Biochemistry
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Sex hormone-binding globulin
Weight loss
polycyclic compounds
Testosterone
Gonadal Steroid Hormones
skin and connective tissue diseases
reproductive and urinary physiology
Estradiol
biology
Middle Aged
Metformin
Primary Prevention
Female
medicine.symptom
hormones
hormone substitutes
and hormone antagonists
Adult
medicine.medical_specialty
Subcutaneous Fat
030209 endocrinology & metabolism
Context (language use)
Estrone
Intra-Abdominal Fat
Risk Assessment
Statistics
Nonparametric
03 medical and health sciences
Dehydroepiandrosterone sulfate
Internal medicine
Glucose Intolerance
Diabetes Mellitus
medicine
Humans
Obesity
Life Style
Clinical Research Articles
business.industry
Biochemistry (medical)
nutritional and metabolic diseases
030104 developmental biology
chemistry
Linear Models
biology.protein
sense organs
business
Program Evaluation
Zdroj: The Journal of Clinical Endocrinology & Metabolism. 102:3381-3389
ISSN: 1945-7197
0021-972X
DOI: 10.1210/jc.2017-00967
Popis: Context The degree to which changes in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) relate to corresponding changes in plasma sex steroids is not known. Objective We examined whether changes in VAT and SAT areas assessed by computed tomography were associated with changes in sex hormones [dehydroepiandrosterone sulfate (DHEAS), testosterone, estradiol, estrone, and sex hormone binding globulin (SHBG)] among Diabetes Prevention Program participants. Design Secondary analysis of a randomized trial. Participants Overweight and glucose-intolerant men (n = 246) and women (n = 309). Interventions Intensive lifestyle change with goals of weight reduction and 150 min/wk of moderate intensity exercise or metformin administered 850 mg twice a day or placebo. Main outcome measures Associations between changes in VAT, SAT, and sex hormone changes over 1 year. Results Among men, reductions in VAT and SAT were both independently associated with significant increases in total testosterone and SHBG in fully adjusted models. Among women, reductions in VAT and SAT were both independently associated with increases in SHBG and associations with estrone differed by menopausal status. Associations were similar by race/ethnicity and by randomization arm. No significant associations were observed between change in fat depot with change in estradiol or DHEAS. Conclusions Among overweight adults with impaired glucose intolerance, reductions in either VAT and SAT were associated with increased total testosterone in men and higher SHBG in men and women. Weight loss may affect sex hormone profiles via reductions in visceral and subcutaneous fat.
Databáze: OpenAIRE
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