Reduced spinal reflexes following intrathecal baclofen in the rabbit
| Autor: | Richard D. Penn, Jeffrey S. Kroin, R C Arzbaecher, R L Beissinger |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Baclofen Stimulation Hindlimb Synaptic Transmission chemistry.chemical_compound Lumbar Reflex medicine Reaction Time Animals Spasticity Injections Spinal Dose-Response Relationship Drug business.industry General Neuroscience Spinal cord body regions medicine.anatomical_structure chemistry Spinal Cord Anesthesia Synapses Rabbits medicine.symptom business Muscle contraction Muscle Contraction |
| Zdroj: | Experimental brain research. 54(1) |
| ISSN: | 0014-4819 |
| Popis: | Intrathecal baclofen is effective in reducing polysynaptic spinal reflexes in awake rabbits. A single lumbar infusion of 2.5-5.0 ng drug caused a significant reduction in the crossed extensor response to electrical stimulation of the plantar surface of the hindlimb. This inhibition lasted 5 h or more. At doses of 3 micrograms or less, the forelimbs were unaffected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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