Experimental Studies and the Search for New Innovative Approaches to Treat Dry Eye Disease

Autor: Sergiy Rykov, Anastasiia Liemienieva, Mykola Petrovsky, Iryna Shargorodska
Rok vydání: 2021
Předmět:
Zdroj: Journal of Education, Health and Sport, Vol 11, Iss 5, Pp 294-302 (2021)
ISSN: 2391-8306
Popis: Liemienieva Anastasiia, Shargorodska Iryna, Rykov Sergiy, Petrovsky Mykola. Experimental Studies and the Search for New Innovative Approaches to Treat Dry Eye Disease. Journal of Education, Health and Sport. 2021;11(05): 294-302. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.05.031 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.05.031 https://zenodo.org/record/5338603 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.05.2021. Revised: 21.05.2021. Accepted: 28.05.2021. Experimental Studies and the Search for New Innovative Approaches to Treat Dry Eye Disease Anastasiia Liemienieva1, Iryna Shargorodska2, Sergiy Rykov2, Mykola Petrovsky3 1Kyiv City Clinical Ophthalmological Hospital “Eye Microsurgery Center”, Ukraine 2Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine 3Taras Shevchenko National University of Kyiv, Ukraine Anastasiia Liemienieva ORCID: 0000-0001-7312-1610 Iryna Shargorodska ORCID: 0000-0001-8958-1849 Sergiy Rykov ORCID: 0000-0002-3495-7471 Mykola Petrovsky ORCID: 0000-0003-3267-7123 Abstract Introduction and purpose. The main manifestation of eyelids, tear ducts, and orbits disorders is a dry eye disease considered as a serious disease that affects the quality of life. Nowadays, one in ten people worldwide faces this disease. Increased workload, development of multimedia technologies, hypodynamia, and environmental degradation are the main modern causes of the disease. Material and methods. In this work, we used an experimental model of dry eye in rats with the development of inflammation of the anterior surface of the eye. Alkali burns were used to develop inflammation. A fluorescein test performed immediately after alkaline erosion and on days 1, 5, and 10 after burns revealed a gradual increase in corneal epithelialization and vascularization. Results. One day after induction of inflammation, there was a dramatic and statistically significant increase in tear production in experimental rats. By the seventh day, tear production declined to the control level with a subsequent tendency to decrease tear production. Conclusions. In the group of rats with inflammation of the anterior surface of the eye that received polarized red-light therapy, there was no significant decrease in tear production on day 7, which may be indicative of a possible anti-inflammatory effect of light therapy under these conditions. Keywords: dry eye disease; inflammation of the anterior surface of the eye; fluorescein test; Schirmer test; polarized light; Bioptron-Pailer therapy.
Databáze: OpenAIRE
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