Airway pressure-time curve profile (stress index) detects tidal recruitment/hyperinflation in experimental acute lung injury
| Autor: | Peter Herrmann, Luciana Mascia, V. M. Ranieri, Michael Quintel, Pierpaolo Terragni, Salvatore Grasso, A. S. Slutsky, Göran Hedenstierna, Fanelli |
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| Přispěvatelé: | GRASSO S, TERRAGNI P, MASCIA L, FANELLI V, QUINTEL M, HERRMANN P, HEDENSTIERNA G, SLUTSKY AS, RANIERI V |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Male
ARDS Pulmonary Atelectasis Swine Hyperinflation Lung injury Critical Care and Intensive Care Medicine Positive-Pressure Respiration Intensive care medicine Tidal Volume Animals Tidal volume Positive end-expiratory pressure Respiratory Distress Syndrome Continuous Positive Airway Pressure business.industry Respiratory disease respiratory system medicine.disease respiratory tract diseases Pulmonary Alveoli Treatment Outcome Anesthesia VILI ARDS stress index business Airway Lung Volume Measurements Tomography X-Ray Computed circulatory and respiratory physiology |
| Popis: | OBJECTIVE: To evaluate whether the shape of the airway pressure-time (Paw-t) curve during constant flow inflation corresponds to radiologic evidence of tidal recruitment or tidal hyperinflation in an experimental model of acute lung injury. DESIGN: Prospective randomized laboratory animal investigation. SETTING: Department of Clinical Physiology, University of Uppsala, Sweden. SUBJECTS: Anesthetized, paralyzed, and mechanically ventilated pigs. INTERVENTIONS: Acute lung injury was induced by lung lavage. During constant inspiratory flow, the Paw-t curve was fitted to a power equation: airway pressure =a x time + c, where coefficient b (stress index) describes the shape of the curve:b = 1, straight curve; b < 1, progressive increase in slope; and b > 1, progressive decrease in slope. Tidal volume (Vt) was 6 mL/kg, and positive end-expiratory pressure was set to obtain a b value between 0.9 and 1.1 before (b = 1) and after (b = 1 after recruiting maneuver) application of a recruiting maneuver. Positive end-expiratory pressure was decreased and Vt increased to obtain 0.9 >b > 0.8 and 0.8 >b > 0.6, whereas positive end-expiratory pressure and Vt were both increased to obtain 1.3 >b > 1.1 and 1.5 >b > 1.3. Experimental conditions sequence was random. MEASUREMENTS AND MAIN RESULTS: Pulmonary computed tomography was obtained during end-expiratory and end-inspiratory occlusions. Tidal recruitment was quantified as nonaerated (between -100 and +100 Hounsfield units) lung area at end-expiration minus end-inspiration. Tidal hyperinflation was quantified as hyperinflated (between -900 and -1000 Hounsfield units) lung area at end-inspiration minus end-expiration. Computed tomography images showed that tidal recruitment and tidal hyperinflation corresponded to b < 1 and b > 1, respectively. Stress index values and tidal recruitment and tidal hyperinflation values were significantly correlated (R =.917 and R =.911, p |
| Databáze: | OpenAIRE |
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