Nano-hybrid electrospun non-woven mats made of wool keratin and hydrotalcites as potential bio-active wound dressings

Autor: Chiara G.M. Gennari, Annalisa Aluigi, Francesco Valle, Tamara Posati, Giovanna Sotgiu, Morena Nocchetti, Marianna Barbalinardo, Roberto Zamboni, Franco Corticelli, Demetra Giuri, Francesca Selmin, Anna Donnadio
Přispěvatelé: Demetra Giuri, Marianna Barbalinardo, Giovanna Sotgiu, Roberto Zamboni, Morena Nocchetti, Anna Donnadio, Franco Corticelli, Francesco Valle, Chiara G. M. Gennari, Francesca Selmin, Tamara Posati, Annalisa Aluigi
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Diclofenac
Magnesium Hydroxide
Biocompatibility
Cell Survival
Anti-Inflammatory Agents
Nanofibers
Aluminum Hydroxide
02 engineering and technology
010402 general chemistry
01 natural sciences
Fluorescence
Mice
Keratin
medicine
Nano hybrid
Animals
General Materials Science
Fibroblast
SOLUTE RELEASE
DRUG-DELIVERY
DICLOFENAC
NANOFIBERS
DIFFERENTIATION
INTERCALATION
MEMBRANES
FIBROIN
FIBERS
BLEND
chemistry.chemical_classification
Microscopy
Hydrotalcite
Viscosity
Wool
Anti-Inflammatory Agents
Non-Steroidal
technology
industry
and agriculture
021001 nanoscience & nanotechnology
Bandages
0104 chemical sciences
Keratin
nanofibres
electrospinning
wound healing
LAYERED DOUBLE HYDROXIDES
Drug Liberation
medicine.anatomical_structure
Microscopy
Fluorescence
chemistry
Chemical engineering
Nanofiber
Drug delivery
NIH 3T3 Cells
Keratins
0210 nano-technology
Non-Steroidal
Shear Strength
Zdroj: Nanoscale
11 (2019): 6422–6430. doi:10.1039/c8nr10114k
info:cnr-pdr/source/autori:Giuri, Demetra; Barbalinardo, Marianna; Sotgiu, Giovanna; Zamboni, Roberto; Nocchetti, Morena; Donnadio, Anna; Corticelli, Franco; Valle, Francesco; Gennari, Chiara G. M.; Selmin, Francesca; Posati, Tamara; Aluigi, Annalisa/titolo:Nano-hybrid electrospun non-woven mats made of wool keratin and hydrotalcites as potential bio-active wound dressings/doi:10.1039%2Fc8nr10114k/rivista:Nanoscale (Print)/anno:2019/pagina_da:6422/pagina_a:6430/intervallo_pagine:6422–6430/volume:11
DOI: 10.1039/c8nr10114k
Popis: In this work, nano-hybrid electrospun non-woven mats made of wool keratin combined with diclofenac loaded hydrotalcites (HTD) were prepared and characterized as potential drug delivery systems and scaffolds for fibroblast cell growth. Nano-hybrid electrospun non-woven mats showed a good adaptability to wet skin, effortlessly conforming to the three-dimensional topography of the tissue. Nanosized HTD exercised an overall reinforcing action on the electrospun non-woven mats since the nanohybrid samples displayed a reduced swelling ratio and a slower degradation profile compared to keratin-based nanofiber non-woven mats containing free diclofenac, without negative effects on drug release. The cell viability test indicated a decreased toxicity of the drug when loaded into nanofibers and confirmed the biocompatibility of keratin/HTD electrospun non-woven mats; moreover, a controlled diclofenac release within the first 24 hours does not compromise the fibroblast cell growth in a significant manner.
Databáze: OpenAIRE
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