Angiotensin II stimulates left ventricular hypertrophy in hypertensive patients independently of blood pressure
| Autor: | Roland E. Schmieder, Christian Delles, Markus P. Schlaich, Johannes Jacobi, Hans P. Schobel |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Mean arterial pressure Ambulatory blood pressure business.industry Hemodynamics Essential hypertension medicine.disease Left ventricular hypertrophy Angiotensin II Endocrinology Blood pressure Internal medicine Renal blood flow Internal Medicine medicine Cardiology business |
| Zdroj: | American Journal of Hypertension. 12:418-422 |
| ISSN: | 0895-7061 |
| Popis: | Angiotensin II (AII) is known to be a growth stimulating factor for myocardial cells. We examined whether an exaggerated responsiveness to AII might aggravate left ventricular (LV) hypertrophy in human essential hypertension. To determine the responsiveness to AII in humans, we examined changes in mean arterial pressure (MAP), renal blood flow (RBF), and glomerular filtration rate (GFR) (steady state input clearance technique with para-aminohippurate and inulin, respectively) and aldosterone secretion to AII infusions (0.5 and 3.0 ng/kg/min) in 71 normotensive male and 48 hypertensive male subjects (age: 26 ± 3 years; 24-h ambulatory blood pressure: 121 ± 5/71 ± 4 mmHg v 138 ± 7/82 ± 7 mmHg, P v 17 ± 8 mm Hg, P v −270 ± 137 mL/min, P P P P P P |
| Databáze: | OpenAIRE |
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