The effect of fast created inbreeding on litter size and body weights in mice

Autor: Theo H E Meuwissen, O. Vangen, Marte Holt
Přispěvatelé: Revues Inra, Import
Jazyk: angličtina
Rok vydání: 2005
Předmět:
0106 biological sciences
Litter (animal)
Male
fast inbreeding
lcsh:QH426-470
media_common.quotation_subject
Population
Population genetics
[SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics
Biology
010603 evolutionary biology
01 natural sciences
03 medical and health sciences
Mice
body weight
Animal science
Control line
Genetics
Inbreeding depression
Animals
Genetics(clinical)
Inbreeding
education
Ecology
Evolution
Behavior and Systematics
mouse
lcsh:SF1-1100
030304 developmental biology
media_common
0303 health sciences
education.field_of_study
Models
Statistical
Models
Genetic
Research
General Medicine
Mating design
lcsh:Genetics
[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics
Animal Science and Zoology
Female
lcsh:Animal culture
Reproduction
litter size
inbreeding depression
Zdroj: Genetics Selection Evolution
Genetics Selection Evolution, BioMed Central, 2005, 37 (5), pp.523-537
Genetics, Selection, Evolution : GSE
Genetics Selection Evolution, Vol 37, Iss 6, Pp 523-537 (2005)
ISSN: 0999-193X
1297-9686
Popis: This study was designed to reveal any differences in effects of fast created versus total inbreeding on reproduction and body weights in mice. A line selected for large litter size for 124 generations (H) and a control line (K) maintained without selection for the same number of generations were crossed (HK) and used as a basis for the experiment. Within the HK cross, full sib, cousin or random mating were practised for two generations in order to create new inbreeding (IBF) at a fast rate. In the first generation of systematic mating, old inbreeding was regenerated in addition to creation of new inbreeding from the mating design giving total inbreeding (IBT). The number of pups born alive (NBA) and body weights of the animals were then analysed by a model including both IBT and IBF. The IBT of the dam was in the present study found to reduce the mean NBA with -0.48 (± 0.22) (p < 0.05) pups per 10% increase in the inbreeding coefficient, while the additional effect of IBF was -0.42 (± 0.27). For the trait NBA per female mated, the effect of IBT was estimated to be -0.45 (± 0.29) per 10% increase in the inbreeding coefficient and the effect of IBF was -0.90 (± 0.37) (p < 0.05) pups. In the present study, only small or non-significant effects of IBF of the dam could be found on sex-ratio and body weights at three and six weeks of age in a population already adjusted for IBT.
Databáze: OpenAIRE
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