Neurological Development of 5-Year-Old Children Receiving a Low–Saturated Fat, Low-Cholesterol Diet Since Infancy
| Autor: | Jorma Viikari, Juhani Tuominen, Olli Simell, Eero Jokinen, Tapani Rönnemaa, Ilkka Välimäki, Helena Lapinleimu, Leena Rask-Nissilä, Ritva Seppänen, Tapio Korhonen, Pirjo Terho, Anne Tammi |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Randomization Saturated fat Gross motor skill Coronary Disease Neuropsychological Tests law.invention Fatty Acids Monounsaturated chemistry.chemical_compound Child Development Randomized controlled trial Risk Factors law Internal medicine medicine Humans Prospective Studies Diet Fat-Restricted Health Education chemistry.chemical_classification Cholesterol business.industry Infant General Medicine Confidence interval Surgery chemistry Child Preschool Relative risk Fatty Acids Unsaturated Energy Intake business Polyunsaturated fatty acid |
| Zdroj: | JAMA. 284:993 |
| ISSN: | 0098-7484 |
| DOI: | 10.1001/jama.284.8.993 |
| Popis: | ContextEarly childhood introduction of nutritional habits aimed at atherosclerosis prevention is compatible with normal growth, but its effect on neurological development is unknown.ObjectiveTo analyze how parental counseling aimed at keeping children's diets low in saturated fat and cholesterol influences neurodevelopment during the first 5 years of life.DesignRandomized controlled trial conducted between February 1990 and November 1996.SettingOutpatient clinic of a university department in Turku, Finland.ParticipantsA total of 1062 seven-month-old infants and their parents, recruited at well-baby clinics between 1990 and 1992. At age 5 years, 496 children still living in the city of Turku were available to participate in neurodevelopmental testing.InterventionParticipants were randomly assigned to receive individualized counseling aimed at limiting the child's fat intake to 30% to 35% of daily energy, with a saturated:monounsaturated:polyunsaturated fatty acid ratio of 1:1:1 and a cholesterol intake of less than 200 mg/d (n = 540) or usual health education (control group, n = 522).Main Outcome MeasuresNutrient intake, serum lipid concentrations, and neurological development at 5 years, among children in the intervention vs control groups.ResultsAbsolute and relative intakes of fat, saturated fatty acids, and cholesterol among children in the intervention group were markedly less than the respective values of control children. Mean (SD) percentages of daily energy at age 5 years for the intervention vs control groups were as follows: for total fat, 30.6% (4.5%) vs 33.4% (4.4%) (P |
| Databáze: | OpenAIRE |
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