Assessment of the toxicity effects of nicotine on sperm and IVF and the potential protective role of silymarin—an experimental study in mice

Autor:	Reza Ahmadi, Ayoob Rostamzadeh, Mohsen Mohammadi, Maasume Shahmohammadi, Amin Hassanvand, Mohammad Rahimi-Madiseh
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine Nicotine Antioxidant lcsh:QH471-489 medicine.medical_treatment medicine.disease_cause Abnormal sperm morphology Andrology 03 medical and health sciences 0302 clinical medicine medicine lcsh:Reproduction Spermatogenesis Sperm motility lcsh:R5-920 030219 obstetrics & reproductive medicine business.industry Alkaloid Obstetrics and Gynecology Sperm 030104 developmental biology Fertility Reproductive Medicine Toxicity business lcsh:Medicine (General) Oxidative stress In vitro fertility medicine.drug Silymarin
Zdroj:	Middle East Fertility Society Journal, Vol 25, Iss 1, Pp 1-9 (2020)
ISSN:	2090-3251
DOI:	10.1186/s43043-020-00025-4
Popis:	Background Male infertility is usually caused via the inability to produce adequate quantities of healthy and active sperms. Nicotine (NIC) is an alkaloid organic compound, predominantly found in the leaves of the tobacco plant. The major part of the nicotine is not ionized, so it can easily pass through cell membranes. Meanwhile, most of the disorders are caused by oxidative stress due to oxygen free radicals and other reactive species. Antioxidant supplements and antioxidant-rich foods can reduce induced oxidative stress without becoming destabilized themselves. This study aimed to examine spermato-protective potential of silymarin (SIL), on sperm and in vitro fertility (IVF) rate in nicotine-treated mice. Results Our results show a significant increase in the number of abnormal sperm morphology after nicotine exposure, when compared to control groups (p < 0.05). On the other hand, SIL had a significant effect on the sperm count at each of the treated doses. Further, in the mice that received nicotine plus silymarin, the viable sperm percentage and the progressive sperm motility were significant (p < 0.05). Also, a significant reduction in the number of two-cell embryos and blastocyst-derived embryo was seen with increment in the number of dead embryos in mice receiving nicotine alone (p < 0.05). Conclusions In conclusion, SIL could support prevention of the adverse reproductive effects of nicotine. Moreover, SIL200 mg/kg may be therefore considered as a spermato-protective agent in dietary and herbal supplements.
Databáze:	OpenAIRE
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