Expression of estrogen receptor α in the mouse cerebral cortex
| Autor: | Alicia K. Dietrich, Ann M. Nardulli, Gwendolyn I. Humphreys |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Longevity Estrogen receptor Biology Biochemistry Article Endocrinology Internal medicine Progesterone receptor medicine Animals RNA Messenger Postnatal day Molecular Biology Estrogen receptor beta Cerebral Cortex Messenger RNA Estradiol Estrogen Receptor alpha Gene Expression Regulation Developmental Reproducibility of Results Mice Inbred C57BL medicine.anatomical_structure Cerebral cortex Mouse Cerebral Cortex Female Receptors Progesterone Estrogen receptor alpha |
| Zdroj: | Molecular and Cellular Endocrinology. 406:19-26 |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2015.02.013 |
| Popis: | Although estrogen receptor alpha (ERα) and 17β-estradiol play critical roles in protecting the cerebral cortex from ischemia-induced damage, there has been some controversy about the expression of ERα in this region of the brain. We have examined ERα mRNA and protein levels in the cerebral cortices of female mice at postnatal days 5 and 17 and at 4, 13, and 18 months of age. We found that although ERα transcript levels declined from postnatal day 5 through 18 months of age, ERα protein levels remained stable. Importantly, expression of the E2-regulated progesterone receptor gene was sustained in younger and in older females suggesting that age-related changes in estrogen responsiveness in the cerebral cortex are not due to the absence of ERα protein. |
| Databáze: | OpenAIRE |
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