Molecular Mimicry of SARS-CoV-2 Spike Protein in the Nervous System: A Bioinformatics Approach

Autor: Andrés Felipe Cuspoca, Pablo Isaac Estrada, Alberto Velez-van-Meerbeke
Rok vydání: 2022
Předmět:
Zdroj: Computational and structural biotechnology journal. 20
ISSN: 2001-0370
Popis: The development of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in record time to cope with the ongoing coronavirus disease 2019 (COVID-19) pandemic has led to uncertainty about their use and the appearance of adverse neurological reactions. The SARS-CoV-2 spike protein (SP) is used to produce neutralizing antibodies and stimulate innate immunity. However, considering the alterations in the nervous system (NS) caused by COVID- 19, cross-reactions are plausible.To identify peptides inA bioinformatics approach was used. To select theA large number of shared pentapeptides between SP andProteins involved in the maintenance of nerve conduction in the central and peripheral NS were identified in
Databáze: OpenAIRE