Relating acute esophagitis to radiotherapy dose using FDG-PET in concurrent chemo-radiotherapy for locally advanced non-small cell lung cancer
| Autor: | Jasper Nijkamp, Michel M. van den Heuvel, Joos V. Lebesque, Margriet Kwint, José Belderbos, Maddalena Rossi, Wilma Uyterlinde, Jan-Jakob Sonke, Wouter V. Vogel |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Locally advanced Fluorodeoxyglucose F18 Carcinoma Non-Small-Cell Lung medicine Carcinoma Esophagitis Humans Radiology Nuclear Medicine and imaging Lung cancer Aged Acute Esophagitis medicine.diagnostic_test business.industry Radiotherapy Planning Computer-Assisted Dose-Response Relationship Radiation Radiotherapy Dosage Chemoradiotherapy Hematology Middle Aged medicine.disease Confidence interval Radiation therapy Dose–response relationship Oncology Positron emission tomography Positron-Emission Tomography Acute Disease Female Radiology Radiopharmaceuticals Nuclear medicine business |
| Zdroj: | Aarhus University Nijkamp, J, Rossi, M, Lebesque, J, Belderbos, J, van den Heuvel, M, Kwint, M, Uyterlinde, W, Vogel, W & Sonke, J J 2013, ' Relating acute esophagitis to radiotherapy dose using FDG-PET in concurrent chemo-radiotherapy for locally advanced non-small cell lung cancer ', Radiotherapy & Oncology, vol. 106, no. 1, pp. 118-123 . |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/j.radonc.2012.09.024 |
| Popis: | To correlate radiotherapy (RT) dose to acute esophagitis (AE) by means of FDG-PET scans acquired after concurrent chemo-radiotherapy (cCRT) for locally advanced non-small-cell lung cancer (NSCLC).Patients treated with 24 × 2.75 Gy were selected on presence of a post-RT PET (PET(post)) scan acquired within 3 months after cCRT. The value of PET(post) in relation to AE was evaluated by comparing the mean esophageal SUV of the highest 50% (mathematical left angle bracket SUV(50%) mathematical right angle bracket) between gr2 and gr ≥ 2AE. The local dose on the esophagus wall was correlated to the SUV and modeled using a power-law fit. The Lyman-Kutcher-Burman (LKB) model was used to predict gr ≥ 2AE. The local dose-response relation was used in the LKB model to calculate the EUD. Resulting prediction accuracy was compared to D(mean), V(35), V(55) and V(60).Eighty-two patients were included (gr2 = 25, gr ≥ 2=57). The mathematical left angle bracket SUV(50%) mathematical right angle bracket ≥ was significantly higher for gr ≥ 2AE (2.2 vs. 2.6, p0.01). The LKB parameters (95% CI) were n = 0.130 (0.120-0.141), m = 0.25 (0.13-0.85) and TD(50) = 50.4 Gy (37.5-55.4), which resulted in improved predictability of AE compared to other predictors.Esophageal uptake of FDG post-cCRT reflects AE severity. Predictability of grade ≥ 2AE was improved by using the local dose-SUV response model, with narrow confidence intervals for the optimized LKB parameters. |
| Databáze: | OpenAIRE |
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