Poly (Adenosine Diphosphate Ribose) Polymerase-1 Single Nucleotide Polymorphism in the 3'-Untranslated Region for Ischemic Stroke Risk Reduction
| Autor: | Lujun Gu, Gangtao Xu, Dinghua Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Untranslated region
medicine.medical_specialty Genotype Poly (ADP-Ribose) Polymerase-1 Single-nucleotide polymorphism Polymorphism Single Nucleotide Cellular and Molecular Neuroscience Developmental Neuroscience Polymorphism (computer science) Internal medicine Diabetes mellitus medicine Humans SNP Genetic Predisposition to Disease 3' Untranslated Regions Stroke Ischemic Stroke Adenosine Diphosphate Ribose business.industry Three prime untranslated region medicine.disease Endocrinology Neurology Case-Control Studies business Risk Reduction Behavior |
| Zdroj: | Current Neurovascular Research. 18:302-306 |
| ISSN: | 1567-2026 |
| Popis: | Objective: To determine the effect of PARP1 polymorphism on gene interactions. Methods: A total of 500 patients and 500 healthy controls were enrolled. Results: Analysis of clinical data showed that patients with stroke, diabetes, hypertension, and elevated serum triglyceride levels had higher levels of alcohol and smoking. The polymorphism of PARP1rs8679 was inversely associated with the risk of ischemic stroke. Patients with PARP1rs8679AG/ GG genotypes had a lower incidence of an initial stroke. Compared with the wild genotype, mRNA levels of PARP1 were reduced. MiR-124-5p directly induced PARP1 inhibition through the gain binding ability of 3 'UTR binding. Conclusion: Single nucleotide polymorphism (SNP) rs8679 in PARP13ʹUTR can prevent ischemic stroke. |
| Databáze: | OpenAIRE |
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