Usefulness of an Erythromycin-Resistant Strain of Mycoplasma pneumoniae for the Fermentation-Inhibition Test
| Autor: | Yasutaka Niitu, Sumio Hasegawa, Hideo Kubota |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1974 |
| Předmět: |
Mycoplasma pneumoniae
medicine.drug_class Tetracycline Antibiotics Erythromycin Administration Oral Biology medicine.disease_cause Microbiology Macrolide Antibiotics Mycoplasma medicine Humans Pharmacology (medical) Pharmacology Drug Resistance Microbial Articles medicine.disease Virology Anti-Bacterial Agents Titer Infectious Diseases Atypical pneumonia Fermentation medicine.drug |
| Popis: | The fermentation-inhibition (FI) test for Mycoplasma pneumoniae was performed with two strains of M. pneumoniae , one susceptible to erythromycin and one highly resistant to erythromycin with cross-resistance to other macrolide antibiotics. Serum titers in children with M. pneumoniae pneumonia who received no antibiotic were similar with the two strains. Children with atypical pneumonia with a transient rise in the FI titer with the susceptible strain proved to have received erythromycin at the time of the rise. They showed no rise in the FI titer done with the erythromycin-resistant strain. Oral administration of erythromycin regularly elevated the serum FI titer when the test was done with the susceptible strain. Use of the resistant strain in the test eliminated this false elevation. Tetracycline and chloramphenicol did not elevate the titer, even with the susceptible strain. Use of the strain of M. pneumoniae resistant to erythromycin provides a true FI antibody serum titer, avoiding the influence of antibiotics. |
| Databáze: | OpenAIRE |
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