A Novel Risk Factor Associated With Colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in Addition to Antimicrobial Treatment
| Autor: | Ivan Hung, Modissa M.L. Ng, Kwok-Yung Yuen, Lisa M.W. Wong, Sally C. Y. Wong, Simon Y.C. So, Radley H.C. Ching, Pak-Leung Ho, W.M. Lee, Pui Hing Chau, Jonathan H. K. Chen, Vincent C.C. Cheng |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty Adolescent Epidemiology medicine.drug_class 030106 microbiology Cephalosporin Antibiotics Gastroenterology Microbiology 03 medical and health sciences Feces Young Adult Risk Factors Internal medicine medicine Humans Prospective Studies Risk factor Prospective cohort study Child Aged Aged 80 and over Cross Infection business.industry Hazard ratio Enterobacteriaceae Infections Infant Proton Pump Inhibitors Odds ratio Middle Aged Antimicrobial Anti-Bacterial Agents Hospitalization Infectious Diseases Carbapenem-Resistant Enterobacteriaceae Logistic Models Concomitant Child Preschool Hong Kong Female business |
| Zdroj: | Infection control and hospital epidemiology. 37(12) |
| ISSN: | 1559-6834 0899-823X |
| Popis: | OBJECTIVETo study the association between gastrointestinal colonization of carbapenemase-producing Enterobacteriaceae (CPE) and proton pump inhibitors (PPIs).METHODSWe analyzed 31,526 patients with prospective collection of fecal specimens for CPE screening: upon admission (targeted screening) and during hospitalization (opportunistic screening, safety net screening, and extensive contact tracing), in our healthcare network with 3,200 beds from July 1, 2011, through December 31, 2015. Specimens were collected at least once weekly during hospitalization for CPE carriers and subjected to broth enrichment culture and multiplex polymerase chain reaction.RESULTSOf 66,672 fecal specimens collected, 345 specimens (0.5%) from 100 patients (0.3%) had CPE. The number and prevalence (per 100,000 patient-days) of CPE increased from 2 (0.3) in 2012 to 63 (8.0) in 2015 (PP=.013), presence of wound or drain (3.12 [1.70–5.71], PP=.004), carbapenems (2.21 [1.10–4.48], P=.027), and PPIs (2.84 [1.72–4.71], PP=.005).CONCLUSIONSConcomitant use of antibiotics and PPIs prolonged duration of gastrointestinal colonization by CPE.Infect Control Hosp Epidemiol 2016;1418–1425 |
| Databáze: | OpenAIRE |
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