Total synthesis of (+/ − )-4-demethylenglerin A

Autor:	Xiaoyu Liu, Xiaoyu Li, Chengsen Tian, Xiaozhen Jiao, Yangyang Yao, Liang Dong, Ping Xie
Rok vydání:	2014
Předmět:	Pharmacology Primary (chemistry) Cytotoxicity test Molecular Structure Chemistry Organic Chemistry Pharmaceutical Science Total synthesis Stereoisomerism General Medicine Sesquiterpene Analytical Chemistry Phyllanthus Sesquiterpenes Guaiane Structure-Activity Relationship chemistry.chemical_compound Complementary and alternative medicine Aldol reaction Cyclization Drug Discovery Humans Molecular Medicine Organic chemistry Cyclic hydrocarbon
Zdroj:	Journal of Asian Natural Products Research. 16:629-639
ISSN:	1477-2213 1028-6020
DOI:	10.1080/10286020.2014.918111
Popis:	Racemic 4-demethylenglerin A (1'), a simplified analog of the guaiane-type sesquiterpene englerin A (1), has been synthesized. The cyclic hydrocarbon core structure was built through modified Metz approach using epoxynitrile cyclization and direct Aldol reaction to prepare the precursor of RCM. The primary cytotoxicity test summarized that C4 methyl has marked impacts on the bioactivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a1cd439c415d8ab6ab2a91cfb761a1 https://doi.org/10.1080/10286020.2014.918111 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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