Ultraflexible nanoelectronic probes form reliable, glial scar-free neural integration
| Autor: | Zhengtuo Zhao, Chong Xie, Stewart Holloway, Ojas Potnis, Shengqing Lin, Catherine A Tuppen, Robert A. Fowler, Raymond A. Chitwood, Lan Luan, Andrew K. Dunn, Xiaoling Wei, Jennifer J. Siegel, S. M. Shams Kazmi |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology medicine.medical_specialty Materials science Biocompatibility biocompatible implant Mice Transgenic 02 engineering and technology Glial scar 03 medical and health sciences Mice 0302 clinical medicine intracortical recording In vivo Materials Testing medicine Animals Noise level Research Articles Multidisciplinary Neural integration Nanoelectronics SciAdv r-articles neural electrode 021001 nanoscience & nanotechnology Electrodes Implanted Nanostructures Microscopy Fluorescence Multiphoton Blood-Brain Barrier ultra-flexible electronics in vivo imaging 0210 nano-technology Neuroglia 030217 neurology & neurosurgery Preclinical imaging Biomedical engineering Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | Subcellular-sized, ultraflexible electrodes form seamless integration with the living brain and afford chronically reliable recording. Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility, and cellular surgical footprints form reliable, glial scar–free neural integration. We demonstrated that NET electrodes reliably detected and tracked individual units for months; their impedance, noise level, single-unit recording yield, and the signal amplitude remained stable during long-term implantation. In vivo two-photon imaging and postmortem histological analysis revealed seamless, subcellular integration of NET probes with the local cellular and vasculature networks, featuring fully recovered capillaries with an intact blood-brain barrier and complete absence of chronic neuronal degradation and glial scar. |
| Databáze: | OpenAIRE |
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