Gene frequencies of platelet-specific antigens in Croatian population
Autor: | Marina Pavić, D. Coen Herak, Renata Zadro, M. Radic Antolic, Slavica Dodig |
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Jazyk: | angličtina |
Rok vydání: | 2010 |
Předmět: |
Adult
Male endocrine system Adolescent Genotype Croatia Platelet disorder Population Population genetics Platelet Membrane Glycoproteins Biology Platelet membrane glycoprotein Young Adult trombocitni antigeni polimorfizam dijete Gene Frequency Antigen Polymorphism (computer science) Humans Antigens Human Platelet Child education Allele frequency Alleles Aged Genetics education.field_of_study Infant Hematology Middle Aged Europe Phenotype Child Preschool Immunology Female hormones hormone substitutes and hormone antagonists |
Popis: | The human platelet antigens (HPA) are genetically defined polymorphisms expressed on platelet membrane glycoproteins. As platelet antigens are very important in several clinical situations and in population genetics, we used the polymerase chain reaction with sequence-specific primers (PCR-SSP) to investigate HPA-1, -2, -3 and -5 allele frequencies in the Croatian population. The HPA frequencies obtained in 219 Croatians were: 1a-0.854, 1b-0.146, 2a-0.890, 2b-0.110, 3a-0.575, 3b-0.425, 5a-0.895 and 5b-0.105. These data are similar to the frequencies reported in most European studies with some significant differences in HPA-2 when compared with the Dutch and German population, in HPA-3 when compared with the Swiss population and in HPA-5 when compared with the Finnish population. The three most common condensed HPA genotypes in the Croatian population were: HPA-1a/a, -2a/a, -3a/b, -5-a/a (0.283), HPA-1a/a, -2a/a, -3a/a, -5-a/a (0.137) and HPA-1a/b, -2a/a, -3a/b, -5-a/a (0.087). Data obtained in this study can be used for better understanding and treatment of immune-mediated platelet disorders in our population. |
Databáze: | OpenAIRE |
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