Circadian Gating of the Cell Cycle Revealed in Single Cyanobacterial Cells
| Autor: | Guogang Dong, Susan S. Golden, Alexander van Oudenaarden, Qiong Yang, Bernardo F. Pando |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Biology, Massachusetts Institute of Technology. Department of Physics, Yang, Qiong, Pando, Bernardo Fabian, van Oudenaarden, Alexander |
| Rok vydání: | 2010 |
| Předmět: |
Cyanobacteria
Light Cell division Gating Models Biological Article Bacterial Proteins Biological Clocks Botany Computer Simulation Circadian rhythm Synechococcus Multidisciplinary biology Circadian Rhythm Signaling Peptides and Proteins Cell Cycle Cell cycle biology.organism_classification Bacterial circadian rhythms Circadian Rhythm Cell biology Luminescent Proteins Microscopy Fluorescence Monte Carlo Method Function (biology) |
| Zdroj: | PubMed Central |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell division events and circadian phases of individual cells of the cyanobacterium Synechococcus elongatus and fit the data to a model to determine when cell cycle progression slows as a function of circadian and cell cycle phases. We infer that cell cycle progression in cyanobacteria slows during a specific circadian interval but is uniform across cell cycle phases. Our model is applicable to the quantification of the coupling between biological oscillators in other organisms. National Science Foundation (U.S.) (NSF grant PHY-0548484) National Institutes of Health (U.S.) (NIH grant R01-GM068957) National Institutes of Health (U.S.) (NIH grant R01-GM062419) |
| Databáze: | OpenAIRE |
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