Fecal calprotectin (FC) in newborns: is it a predictive marker of gastrointestinal and/or allergic disease?
| Autor: | Roberto Grosso, A. Laneve, Maria Elisabetta Baldassarre, M.R. Falcone, Margherita Fanelli, Maria L. Lasorella, Nicola Laforgia |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Allergy Pediatrics medicine.medical_specialty Gastrointestinal Diseases Immunology Disease Toxicology Atopy Feces Predictive Value of Tests Surveys and Questionnaires medicine Hypersensitivity Prevalence Immunology and Allergy Humans Predictive biomarker Pharmacology Predictive marker business.industry Infant Newborn Infant General Medicine medicine.disease Gastrointestinal disease Child Preschool Female Calprotectin business Leukocyte L1 Antigen Complex Biomarkers |
| Zdroj: | Immunopharmacology and immunotoxicology. 33(1) |
| ISSN: | 1532-2513 |
| Popis: | Fecal calprotectin seems to provide a safe and non-invasive means of helping differentiate between patients with organic and non-organic intestinal disease. Aim of our study was to evaluate if FC levels at birth and at first month of age can be a predictive biomarker of organic or functional gastrointestinal disease (FGIDs) and/or allergic disease diagnosed in 2 years old children. Between December 2007 and January 2008 a telephonic interview has been proposed to the parents of 109 consecutive healthy children, in which FC was measured at birth two years before. For our study, a modified version of the original paediatric questionnaire on paediatric functional gastrointestinal disorders (QPGS) was used for the interview. Specific questions were added to detect allergic diseases. We did’nt find any statistically significant result between FC measured at birth and during first month of life in children with allergy or not. The interference of familiarity does not lead to a statistically significant change in the fecal calprotectin values during the first month of life. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|