Smallpox vaccination and ischemic coronary events in healthy adults
| Autor: | Robert E. Eckart, Eric A. Shry, J. Edwin Atwood, John D. Grabenstein, John F. Brundage, Thomas F. Bateson, Jenny C. Lay |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Acute coronary syndrome Population Myocardial Ischemia Coronary artery disease Angina Internal medicine medicine Adverse Drug Reaction Reporting Systems Humans Smallpox Myocardial infarction education education.field_of_study General Veterinary General Immunology and Microbiology Immunization Programs business.industry Vaccination Public Health Environmental and Occupational Health Middle Aged medicine.disease United States Surgery Military Personnel Infectious Diseases Molecular Medicine Female business Smallpox Vaccine Myopericarditis |
| Zdroj: | Vaccine. 25:8359-8364 |
| ISSN: | 0264-410X |
| Popis: | Although smallpox vaccine-associated myopericarditis has been reported, the risk of cardiac ischemic events remains uncertain. We identified personnel receiving the smallpox vaccination and compared them to a historical referent population. The rate of cardiac ischemia diagnoses in the 30 days following smallpox vaccination was 140.1 per 100,000 person-years, compared to 143.5 per 100,000 person-years in referent group (RR 1.0 [95% CI: 0.7-1.4]). The rate of cardiac ischemic events in vaccinees was 121.4 per 100,000 person-years before and 175.7 after adopting pre-vaccination cardiac screening (RR 1.4 [95% CI: 0.8-2.7]). Implementation of pre-vaccination cardiac risk factor screening was not associated with a reduction in cardiac events. |
| Databáze: | OpenAIRE |
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