Promising Anticancer Activity of [Bis(1,8-quinolato)palladium (II)] Alone and in Combination
| Autor: | Mohammad Ali Moni, Nur Alam, M. Pear Hossain, Nick Proschogo, Mohammad Azizur Rahman, Peter Turner, Philip Beale, Jun Q. Yu, Fazlul Huq |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Models Molecular inorganic chemicals QH301-705.5 chemistry.chemical_element Antineoplastic Agents cancer palladium 8-Hydroxyquinoline proteomics Epigallocatechin gallate Pharmacology Catalysis Article Inorganic Chemistry chemistry.chemical_compound Mice Coordination Complexes Cell Line Tumor Neoplasms parasitic diseases medicine Animals Humans Protein Interaction Maps Physical and Theoretical Chemistry Biology (General) Molecular Biology IC50 QD1-999 Spectroscopy Cisplatin Ligand Chemistry Organic Chemistry Cancer General Medicine Quinolinic Acid medicine.disease Computer Science Applications Cell culture Curcumin Palladium medicine.drug |
| Zdroj: | International Journal of Molecular Sciences; Volume 22; Issue 16; Pages: 8471 International Journal of Molecular Sciences, Vol 22, Iss 8471, p 8471 (2021) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22168471 |
| Popis: | Due to similar coordination chemistry of palladium and platinum, a large number of palladium compounds as well have been investigated for their anticancer activity. In the present study, we describe synthesis, characterization, and anticancer activity of palladium complex [Bis(1,8-quinolato)palladium (II)], coded as NH3 against seven different cancer cell lines. NH3 is found to have higher antitumor activity than cisplatin against both parent ovarian A2780 cell line and cisplatin-resistant cell lines. Also, NH3 has the lower IC50 value in HT-29 colorectal cancer cell line. The higher antitumor activity of NH3 is due to the presence of bulky 8-Hydroxyquinoline ligand, thus reducing its reactivity. Proteomic study has identified significantly expressed proteins which have been validated through bioinformatics. NH3 has been found to be less toxic than cisplatin at 2.5 mg/kg and 5 mg/kg dosages on mice models. Binary combinations of NH3 with curcumin and epigallocatechin gallate (EGCG) have demonstrated dose and sequence-dependent synergism in ovarian and colorectal cancer models. All of the preclinical studies indicate promising therapeutic potential of NH3 [Bis(1,8-quinolato)palladium (II)] as an anticancer drug. |
| Databáze: | OpenAIRE |
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