α-Amylase inhibition, cytotoxicity and influence of the in vitro gastrointestinal digestion on the bioaccessibility of phenolic compounds in the peel and seed of Theobroma grandiflorum
| Autor: | Christean Santos de Oliveira, Julianna Karla Santana Andrade, Romy Gleyse Chagas Barros, Ubatã Corrêa Pereira, Narendra Narain, Nayjara Carvalho Gualberto, Saravanan Shanmugam |
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| Rok vydání: | 2021 |
| Předmět: |
Cacao
Antioxidant Bifidobacterium longum biology Chemistry medicine.medical_treatment Vanillin food and beverages Ethyl gallate General Medicine Epigallocatechin gallate biology.organism_classification Antioxidants Analytical Chemistry chemistry.chemical_compound Phenols Lactobacillus medicine biology.protein Digestion Amylase Food science Gallic acid alpha-Amylases Food Science |
| Zdroj: | Food chemistry. 373 |
| ISSN: | 1873-7072 |
| Popis: | The aim of this work was to evaluate the bioaccessibility, cytotoxicity, antioxidant and antidiabetic potential of peel and seeds of cupuassu (Theobroma grandiflorum). Thus, the extracts of cupuassu were evaluated for inhibition of α-amylase, cytotoxicity, and bioaccessibility after gastrointestinal digestion and probiotic fermentation (Lactobacillus delbrueckii, Lactobacillus jhonsoni, Lactobacillus rhamus and Bifidobacterium longum). Digestion increased concentrations of phenolics, showing bioaccessibility of up to 274.13% (total phenolics) and 1105.15% (ORAC). β-carotene, quinic, tartaric, malic, citric, epicatechin, ethyl gallate, epigallocatechin gallate, gallic acid, pyrocatechol, vanillin, ramnetine were the main compounds while the epicatechin, ethyl gallate, gallic acid and pyrocatechol were the major effective phenolic compounds. The extracts did not show toxic effects and the cupuassu seeds showed 97% inhibition of α-amylase and 47.91% bioaccessibility of pyrocatechol. This study suggests that cupuassu extracts are sources of natural antioxidants with promising antidiabetic potential, and probiotics are able to increase phenolic compounds, responsible for health benefits. |
| Databáze: | OpenAIRE |
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