Expression of Steroid Receptors, Ki-67, and p53 in Uterine Leiomyosarcomas
| Autor: | Yaeko Kobayashi, Ya Li Zhai, Toshio Nikaido, Shingo Fujii, Ikuo Konishi, Atsushi Mori, Ayaka Orii |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Leiomyosarcoma medicine.medical_specialty Pathology Estrogen receptor Biology Pathology and Forensic Medicine Internal medicine Progesterone receptor medicine Humans Receptor Aged Oncogene Reverse Transcriptase Polymerase Chain Reaction Obstetrics and Gynecology Middle Aged Prognosis medicine.disease Immunohistochemistry Ki-67 Antigen Endocrinology Leiomyoma Receptors Estrogen Mutation Uterine Neoplasms Smooth Muscle Tumor Cancer research Female Tumor Suppressor Protein p53 Receptors Progesterone |
| Zdroj: | International Journal of Gynecological Pathology. 18:20-28 |
| ISSN: | 0277-1691 |
| DOI: | 10.1097/00004347-199901000-00004 |
| Popis: | The expression of estrogen receptor (ER), progesterone receptor (PR), tumor suppressor oncogene p53, and Ki-67 was compared in uterine smooth muscle tumors, including leiomyosarcoma (LMS), tumor of uncertain malignant potential (UMP), cellular leiomyoma (CL), bizarre leiomyoma (BL), and usual leiomyoma (UL). ER and PR were expressed in all ULs. PR was expressed in UL irrespective of the phase of the menstrual cycle; this staining was also observed in CL, UMP, and BL, although BL showed variable staining for ER. Compared to these tumors, the expression of both ER and PR was markedly reduced in LMS. The results of ER and PR transcripts by reverse transcription-polymerase chain reaction were compatible with those of immunohistochemistry. The number of Ki-67 positive cells in LMS was significantly higher than in UMP, BL, CL, and UL. p53 immunoreactivity was seen in 10 of 14 LMSs, and missense mutation in the p53 gene was found in 4 of 10 LMSs. These results suggest that abnormal expression of ovarian steroid receptors, p53, and Ki-67 is frequently associated with LMS of the uterus. |
| Databáze: | OpenAIRE |
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