Assessment of plasma antioxidant capacity and oxidative stress in HIV/AIDS patients in Calabar, Nigeria
| Autor: | Ebot Walter Ojong, Forwah Jacques Ndeh, MH Etukudo, Chinyere Adanna Opara Usoro, Vigny Njeodo Njongang, Jules Destin Mela Djeufouata, Augusta Chinyere Nsonwu-Anyanwu, Iya Eze Bassey |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antioxidant Science medicine.medical_treatment medicine.disease_cause Antioxidants chemistry.chemical_compound Acquired immunodeficiency syndrome (AIDS) Internal medicine Medicine Depression (differential diagnoses) Multidisciplinary Vitamin C business.industry Public health Oxidants Malondialdehyde medicine.disease Calabar Cytokine chemistry Oxidative stress HIV/AIDS business |
| Zdroj: | Scientific African, Vol 14, Iss, Pp e01017-(2021) |
| ISSN: | 2468-2276 |
| DOI: | 10.1016/j.sciaf.2021.e01017 |
| Popis: | HIV/AIDS remains a global public health challenge especially in countries in sub-Saharan Africa. Management of HIV/AIDS with ART enables patients to lead longer lives but causes changes in biochemical mechanisms, one of which is oxidative stress. The replication of HIV provirus by various pathways is activated by oxidative stress due to high cytokine and antigenic activities. However, there is a paucity of data on oxidative stress among HIV infected patients in Nigeria. The aim of this study was to compare the occurrence of oxidative stress among HIV/AIDs patients on ART and ART-naïve patients at the University of Calabar Teaching Hospital, Calabar, Nigeria.Between January 2017 and February 2018, three groups of participants (n = 225) namely; ART-naïve patients, patients on ART and controls were recruited. Serum uric acid, malondialdehyde, vitamin C and total plasma peroxides concentrations were determined using colorimetric methods. Total serum antioxidant capacity was determined using enzyme –linked immunosorbent assay. The association between each marker of oxidative stress and CD4+ cell count was determined by Pearson's correlation.Male participants had a higher (P ≤ 0.05) serum uric acid level compared to the female participants. HIV negative individuals had a higher (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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