Time and frequency domain analyses of heart rate variability in patients with epilepsy

Autor: Omur Kuru, Asuman Kaftan, Mustafa Kilic, Halil Tanriverdi, Dursun Dursunoglu, Unal Unlu, Harun Evrengul
Rok vydání: 2005
Předmět:
Male
Tachycardia
Time Factors
population
Autonomic disease
Functional Laterality
Epilepsy
Heart Rate
Heart rate variability
time
statistical significance
analytic method
clinical article
recording
medicine.diagnostic_test
adult
article
heart rate variability
female
priority journal
Neurology
RR interval
Cardiology
cholinergic activity
medicine.symptom
Adult
medicine.medical_specialty
frequency analysis
Autonomic Nervous System
Sudden death
Central nervous system disease
male
Internal medicine
Heart rate
medicine
Humans
controlled study
human
Retrospective Studies
Chi-Square Distribution
business.industry
medicine.disease
Surgery
Autonomic nervous system
Case-Control Studies
Electrocardiography
Ambulatory
Neurology (clinical)
business
Electrocardiography
sympathetic tone
tonic clonic seizure
Zdroj: Epilepsy Research. 63:131-139
ISSN: 0920-1211
Popis: Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance of autonomic nervous system in patients at risk of sudden death (SD). SD is more common in patients with epilepsy and the exact mechanisms of SD are unknown. Autonomic nervous system involvement in patients with epilepsy has rarely been studied and has shown conflicting results. Our purpose was to determine if HRV showed any changes in patients with epilepsy in comparison with normal population. A short period analysis of HRV was performed for both the frequency and time domain in 43 epilepsy patients who had generalized tonic-clonic seizures (GTCS) and who were not taking any medications and also in 43 age and sex matched controls. In the time domain analysis, patients displayed higher SDNN (standard deviation of all R-R intervals), SDANN (standard deviation of mean NN intervals in 5 min recordings) and HRV triangular index than did healthy subjects (p < 0.0001). Patients tended to display higher pNN50 (number of R-R intervals differed by >50 ms from adjacent interval divided by the total number of all R-R intervals) and RMSSD (root-mean-square of successive differences) values than did healthy subjects, but the differences were not statistically significant (p > 0.05). In the frequency domain analysis, the spectral measures of HRV showed a reduction of high frequency (HF) values (is a marker of parasympathetic activity) and an increase of low frequency (LF) values (is a measure of sympathetic activity); as a result, the ratio between low and high frequencies (LF/HF) was significantly increased (p < 0.0001, p < 0.0001 and p < 0.001, respectively). Our data suggests an increase in the sympathetic control of the heart rate in epilepsy patients who have GTCS. This increased sympathetic activity could play a key role in the development of ventricular tachyarrhythmias in patients with epilepsy and may be related to the higher incidence of sudden death in this disorder as compared to controls. © 2005 Elsevier B.V. All rights reserved.
Databáze: OpenAIRE
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